Continuity mistake: Lwaxana and Deanna get in an elevator and Deanna tells it to go to Deck 8. But when they arrive the sign says 12 Turbolift.
Character mistake: When Troi is talking with Picard and Dr. Crusher about what's wrong with her mother, she says that "something was happening in her metaconscious mind." Dr. Crusher then asks "metaconscious?" As a Star Fleet doctor, she's had to study the neurology of Betazoids, Vulcans, and other telepaths. She should be familiar with the concept. (Yes, it's expository dialogue for us, the audience, however, Picard is in this scene too and it would have made more sense for him to ask about it.) (00:17:55)
Answer: He brought the Borg to the Alpha Quadrant and showed them that it was full of worlds waiting to be assimilated. Guinan's homeworld was their first stop, and they assimilated everyone and took over the planet, leaving The Survivors of her race without a home. Q is ultimately responsible for that.
Captain Defenestrator
By the time Q takes the Enterprise to meet the Borg, Guinan already knew who they were and they had already destroyed her world. Therefore the above answer can not be right. I believe Guinan is much more than she appears, and her people have had encounters with the Q in the past. It is these interactions, that obviously were not pleasant, that fuels her distrust.
oldbaldyone
That's what the above answer is saying. Q brought the Borg to the Alpha Quadrant (not Earth) and the Borg destroyed Guinan's home world in the late 2200's, which is why she hates Q. Although she met Q in 2160 and they both saw each other as enemies right away.
Bishop73