Continuity mistake: When Picard, Ro and the others arrive at the refugee camp to meet with Keeve Falor, the type of uniform top Ro is wearing has its zipper at the back in the center - with no seam whatsoever at the front. When she kneels down in front of the young child, it has changed to the open-front jacket type, so Ro can touchingly give it to this child.
Continuity mistake: When Ro and Picard are among Ro's people and she gives her jacket to a child (saying something like 'this is what I was, once') she never removes her commbadge. However, there's a commbadge neatly placed on her grey tank top - even though she didn't even remove it from the jacket, let alone put it on her shirt.
Answer: He brought the Borg to the Alpha Quadrant and showed them that it was full of worlds waiting to be assimilated. Guinan's homeworld was their first stop, and they assimilated everyone and took over the planet, leaving The Survivors of her race without a home. Q is ultimately responsible for that.
Captain Defenestrator
By the time Q takes the Enterprise to meet the Borg, Guinan already knew who they were and they had already destroyed her world. Therefore the above answer can not be right. I believe Guinan is much more than she appears, and her people have had encounters with the Q in the past. It is these interactions, that obviously were not pleasant, that fuels her distrust.
oldbaldyone
That's what the above answer is saying. Q brought the Borg to the Alpha Quadrant (not Earth) and the Borg destroyed Guinan's home world in the late 2200's, which is why she hates Q. Although she met Q in 2160 and they both saw each other as enemies right away.
Bishop73