Continuity mistake: Watch when Geordi on the bridge calls up Dr. Crusher in Sick Bay. There's a white-haired medical assistant working on someone behind Geordi. Then when Dr. Crusher responds to Geordi's page, the same assistant is down in Sick Bay with her. Then they cut back to Geordi and the assistant is back up on the bridge again.
Continuity mistake: When Beata tells Riker that he attracts her like no other man, her hand disappears from his neck.
Continuity mistake: When Wesley Crusher and his school chum accidentally hit Picard with a snowball from the holodeck doorway, it makes a huge wet spot on the captain's left shoulder. However, when Picard tells them "Don't let it happen again," as he turns to walk away, the wet spot is now suddenly dry. (00:36:00)
Answer: He brought the Borg to the Alpha Quadrant and showed them that it was full of worlds waiting to be assimilated. Guinan's homeworld was their first stop, and they assimilated everyone and took over the planet, leaving The Survivors of her race without a home. Q is ultimately responsible for that.
Captain Defenestrator
By the time Q takes the Enterprise to meet the Borg, Guinan already knew who they were and they had already destroyed her world. Therefore the above answer can not be right. I believe Guinan is much more than she appears, and her people have had encounters with the Q in the past. It is these interactions, that obviously were not pleasant, that fuels her distrust.
oldbaldyone
That's what the above answer is saying. Q brought the Borg to the Alpha Quadrant (not Earth) and the Borg destroyed Guinan's home world in the late 2200's, which is why she hates Q. Although she met Q in 2160 and they both saw each other as enemies right away.
Bishop73