Continuity mistake: When Zeke is sitting in the hospital, next to medical equipment, it disappears from the scene when he stands up and walks away. (00:23:53)
Continuity mistake: Michaela was shot on her right side, but when she meets Zeke on the street, she is holding her left side.
Continuity mistake: In the hospital ben sits next to his wife's bed. Ben has no glasses on. In one cut he has the glasses on and the next they are gone again, then a few seconds later you see him put on the glasses. (00:19:00)
Answer: Only superficially. Manifest doesn't even begin with a plane crash, but rather a plane disappearing for 5 years with the assumption that it crashed, which turns out not to be true.
BaconIsMyBFF
In the particulars it seems different, but the overall plot is the same. A seemingly random group on an airplane experience a weird event and spend years trying to figure out what happened. Let's hope the reveal in the final episode is not as disappointing as "LOST" - they're actually all dead.