Factual error: When in Amsterdam, there are a number of mistakes with Hanna's car. First off, it's a brand new model, but it has a numberplate from a series six years ago. Second, that numberplate is a flat sticker, while Dutch numberplates are made with very thick plastic letters. Third, the registration is 87-UYM-3, which wouldn't be used, given that Dutch numberplates don't use vowels.

Designated Survivor (2016)
1 factual error in show generally - chronological order
Starring: Kiefer Sutherland, Natascha McElhone, Kal Penn, Adan Canto, Italia Ricci
Continuity mistake: Agent Wells is chasing the bad guy on foot. In the first shot her SIG is not cocked. In the next shot it is cocked. In the next shot the slide is retracted. In the next shot she somehow magically fires it. Then the hammer is somehow forward again. A few seconds later as she climbs the stairs it supernaturally transforms into a Glock. And at no time does she use a proper grip on the gun.
Seth Wright: Mr. President.
Tom Kirkman: You don't need to get up every time I walk into a room. I'm not the Queen.
Seth Wright: No, sir. Virtually no resemblance.
Question: Why did Lyor, Mike, Brenda, Hookstaten, and Chuck randomly disappear from the series?
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Answer: It's a recurring theme on the show. Characters come and go depending on the storyline. General Cochrane, Tyler Richmond, Abe Leonard, etc.