In Search of Lost Time - S3-E15
Continuity mistake: When Samantha sees the surveillance video of her transformation into Reign, which was triggered by Lena provoking her, their dialogue is slightly, but very distinctly, different than it was a few minutes earlier. (00:20:15 - 00:25:25)
Answer: For one, it's usually cheaper to film in Vancouver because of the tax breaks. But all the CW Arrowverse shows (with the exception of "Black Lighting") are/were filmed in Vancouver. So it makes it easier and cheaper for sharing set designs, crossovers, etc ("Black Lightning" filmed in Vancouver during its crossover). Originally "Supergirl" wasn't part of the Arrowverse when it was on CBS, but it was too expensive to produce and wasn't reaching the wider audience the CW shows had. So CBS moved it to its sister company, The CW.
Bishop73