Continuity mistake: Prometheus is flown into the alien spacecraft, presumably to disable it from flying. However, after the alien craft has crashed and rolled over Meredith Vickers, the ship is facing face down on the planet, giving us a full shot of the back of the ship. There is no damage to the back of the bulkhead whatsoever, even after the bright explosion in the atmosphere. (01:43:00)
Continuity mistake: Upon entering the alien ship, Shaw can be seen holding a single-bulb flashlight, right after Fifield begins howling as he releases his "pups". But later on when Holloway notices the CO2 levels, she is holding a triple-bulb flashlight.
Revealing mistake: When Shaw goes to the med pod for her emergency surgery, as she quickly taps on the entrance door to the med-pod room, on the left-hand side of the frame you can see the door is already partially open and then opens before Shaw has finished typing in the code.
Factual error: When Shaw sacrifices the engineer to the alien she rolls out of the escape pod and lands with her hand and Holloway's ring showing. If the atmosphere was that toxic she would be dead and the suit would not be able to hold air pressure,.
Suggested correction: If the air is toxic, that doesn't mean she'd die from it right away. And the air pressure doesn't matter as it's been established that the pressure on the planet is about the same as what they are used to, or is in their suits when the other crew member removed his helmet before.
Continuity mistake: After Elizabeth tells Janek the engineer is headed for Earth and it needs to be stopped, Vickers shouts to Janek, "Captain, let's go." Janek is then shown looking downwards with his lips clenched shut and his eyes are clenched a bit. In the next shot, his mouth is suddenly open and unclenched, looking straight forward with no time to do so.
Other mistake: Charlie gets up and goes to the bathroom, where he finds a sink full of water ready for him, although he didn't ask a machine to do it and he didn't fill it himself.
Other mistake: When Dr Shaw is in the medical "machine", and she wants an abdominal operation, a voice says, "Preparing anaesthetics," but all it does is wipe a line on her stomach with something brown - could be betadine. But Shaw screams and yells in pain. If it really is a "machine" that can perform surgery, well, surely it could put the patient under an anaesthetic that knocks them out, properly.
