Continuity mistake: The chunks of ice in the asylum dunking scene appear and disappear. When Lawrence is brought to the surface, he has two chucks of ice on him that fall off leaving none, but when the shot cuts to him being raised and locked upright, there's a chunk of ice on his right arm. A minute later when he's lowered again into the tank, there's a large chuck by his hip but vanishes when the shot switches showing Lawrence's left side. (01:07:45)
Continuity mistake: In the scene where Benicio Del Toro is in the tavern listening to the townsfolk discuss his brother's death, you see him finish his alcoholic beverage, however, in the next shot his glass jumps to being half full.
Continuity mistake: When Lawrence is going through his first transformation in the mausoleum, his hand is right next to a candle. In the next shot, he is near the door leading out off the mausoleum.