Factual error: In the movie, Henry tells a White House rep that Blackout lasts for 3 minutes, and if they are not back in 4, then they'll know they didn't survive. This is actually not correct. During the Apollo program, blackout typically lasted about 4 minutes. Also, Apollo 13's re-entry blackout in fact lasted 6 minutes, not 4 as seen in the movie, which was 87 seconds longer than predicted.
Factual error: In the scene where Marilyn Lovell is in her backyard and she looks up at the jet flying over her house (presumably her husband), there is a contrail behind it. The jet is at too low of an altitude to produce a contrail.
Factual error: The Apollo 13-Saturn V vehicle was rolled out to the launch pad on 16 Dec 1969, not two days before launch, as portrayed.
Factual error: During the final voiceover, Jim Lovell says "Fred Haise was going back to the moon on Apollo 18, but his mission never flew." In reality, it was Apollo 19, not 18, that Haise was tentatively chosen to command.
Factual error: The remaining smoke plume after the Saturn V liftoff is about 80 miles too low. It's apparent that an aircraft flew over the space center to leave a feeble 'movie' plume. Also, when the Apollo 13 crew blasts out of Earth orbit, the ship is pointed straight at the Moon, meaning that once they travelled the 240,000 miles to the Moon's orbit path, the Moon would be several thousand miles to their left.
Continuity mistake: While the first stage of the Saturn V is fuelled by kerosene and LOX and burns with a bright orange flame, the second and third stages are fuelled by hydrogen and LOX, which has an invisible flame. In the movie all three stages burn with bright orange flames.
Continuity mistake: While the flight director (Gene) is talking to a guy about bringing the spacecraft's power down, there is a side shot of Gene saying: "that's the deal?" now, his hands are in front of him (playing with a pen) the very next shot he has his hands by his side and the man next to him has his head in a different position (a very short time to move your arms and head like that).
Other mistake: When Apollo 13 lifts off, you hear a voice saying something like 'Houston we have cleared the tower at 13:13'. However, when this is said the Saturn V rocket has nowhere near cleared the tower.
Factual error: Hanks as Lovell drives a red corvette. The real Lovell has said in interviews he drove a blue corvette.
Continuity mistake: When Lovell and Haise discuss their families and Haise's illness, Lovell grabs a picture of Mary from the air and comments on, while Haise is seen putting a green letter back into its envelope. It cuts to show a close-up of Haise's hands pulling the letter and the photo from the envelope as if he just opened it (which would have happened moments earlier).
Factual error: At the end of the movie, when the astronauts debark from the helicopter and are surrounded by the crew of the U.S.S. Iwo Jima, there are a number of junior enlisted men wearing combination caps. (The type worn by Chief Petty Officers and commissioned officers.) That they are junior enlisted men is obvious by the rank insignia on their left sleeves and by the silver USN and Eagle emblem on their caps. (Chief's caps have a large gold and silver anchor insignia, and officer's caps have a large gold officer's crest.) The U.S. Navy did, for a few years, replace the junior enlisted men's traditional white hat with the combination cap, but the change was not announced until 1972, two years after the Apollo 13 mission, and the Navy reverted to white hats in 1983, twelve years before the movie was made.
Continuity mistake: The direction of the spacecraft keeps changing. After the extraction of the LM (Lunar Module), the craft is travelling with the CSM (Command/Service Module) engine bell facing forward. After the explosion, it is shown with the LM facing forward. Going around the moon, and back to earth, the CSM is again facing forward.
Suggested correction: The orientation of the spacecraft was not constant. There is no reason why it should be (and, indeed, good reason why it won't). Apollo 13 did indeed have the LM leading at some points and the CSM leading at others.