Continuity mistake: In the opening scene, the pages change in the magazine that the convenience store clerk is reading. (00:01:30)
Continuity mistake: In the liquor store, Seth kicks a shelf to get lighter fluid. Look closely - it is an overhead kick which means that his foot would be upside down. However Seth's foot is the right way round. (00:07:45)
Factual error: When Richie shows the hole in his hand to Seth, it runs right through the tendons of his middle finger. Such a wound would prevent Richie from being able to open and clench that finger, but he doesn't appear to have any trouble. (00:10:35)
Continuity mistake: At the motel, as Seth and the owner are talking, the owner is hunched over. It cuts to his face and he is standing erect. (00:11:50)
Continuity mistake: When Seth introduces Gloria to Mr. .44, the gun is level and pointed at the door. Cut to over Seth's shoulder and the gun is pointed at the ceiling. (00:14:55)
Continuity mistake: After Seth and Richie capture the Fullers, Seth sends Richie outside to start the car. Richie picks up the keys, stands up facing Kate, then exits past her to the right. As the door closes, she is standing against the wall - he would have walked to the left to pass her. (00:29:00)
Continuity mistake: Right after the Geckos capture the Fullers and are driving off, Seth is talking to Jacob in the front seat. The light and shadow on Jacob's hat change between shots on his face and shots on Seth. (00:32:00)
Continuity mistake: At one point the RV is going down a rough, bumpy road and inside Seth and Richie are talking and everything is perfectly still. (00:42:30)
Visible crew/equipment: During the scene where the Geckos first enter the Titty Twister, right after the shot where Seth takes the bottle of whiskey and glasses from the bar the camera cuts between shots of the bar, right after the band finishes the song a camera is visible in the lower right corner. (00:50:25)
Continuity mistake: As Santanico Pandemonium begins her dance, she tosses her cloak off and a stage hand emerges to remove it almost immediately. The stage hand then disappears in two shots of Santanico onstage, then reappears folding the cloak. (00:55:00)
Continuity mistake: As Santanico begins her dance, she swirls her cape. On the third "swirl" a snake appears. The camera shot goes to behind her and the snake's head is working its way up her back. Then in the next shot, the snake's head is round the front and works its way upwards towards her head. (00:55:20)
Continuity mistake: During Santanico Pandemonium's routine, two dancers take the snake away so she can step forward. As they take the snake off, the second dancer is holding only a couple feet of the snake's tail, but in the next shot, the second dancer is holding the entire snake. (00:55:40)
Audio problem: When the Geckos shoot Chet Pussy, the sounds of gunfire don't match the visible gunshots. (01:00:25)
Continuity mistake: When Richie stabs the bartender, the blood on the knife is green, however, throughout the rest of the movie, all the other vampires have red normal blood in them. (01:00:35)
Suggested correction: Not true. When Kate shoots Scott when he's being attacked by the vampires and they explode, you can see green blood dropping to the floor.
Continuity mistake: When Sex Machine turns into a vampire, he covers his mouth so he doesn't show his fangs. When his hand changes, he tries to cover it up with his other hand. Watch this other hand. In the shot where THAT hand changes, it is in a different position from before. (01:21:35)
Plot hole: When Seth's piledriver gives out during the climactic fight, there are many vampires in the background politely keeping their distance while he tries to restart it. Similarly, they ignore him while both his hands are occupied with Sex Machine's whip, even though vampires are running around behind him to no apparent goal. (01:31:35)
Continuity mistake: While Seth is talking to Carlos about the loss of his brother and Kate's family, Kate turns around to survey the damage. Two quick cuts later and she's facing exactly as she was before, down to the facial expression. (01:38:15)
Revealing mistake: When George Clooney is talking to Juliette Lewis towards the end of the film, it is painfully obvious that his tattoo has been smudged. (01:40:35)
Revealing mistake: The closing shot is obviously on a matte painting - the perspective on the ziggurat's corners is off. (01:42:15)
Continuity mistake: Throughout the entire film the tattoo on George Clooney's neck moves position and changes shape.