Trivia: This film features the Serpent Society as secondary antagonists. They were originally jokingly teased as the main antagonists and subtitle at the announcement of Captain America: Civil War before that film's actual title was revealed a few minutes later.
Trivia: In the comics, Ruth Bat-Seraph goes by the codename Sabra and is a Mossad agent. Due to the ongoing conflict between Israel and Gaza, her codename was omitted from the film, and her background as a Mossad agent was dropped in favour of her being a former Black Widow.
Trivia: Prior to appearing in this film, Giancarlo Esposito expressed interest in playing either Professor Xavier or Magneto in the MCU's eventual iteration of X-Men.
Trivia: This film's original subtitle was "New World Order", which is also the name of an episode of "The Falcon and the Winter Soldier" of which this film is a sequel.
Trivia: This is the first MCU film since 2008's The Incredible Hulk to feature Liv Tyler as Betty Ross and Tim Blake Nelson as Samuel Sterns a.k.a. The Leader. They were the last two of that film's five main characters to reappear in the franchise.