Factual error: At the start of the film when Dr. Atkins is ejecting the escape pod from the space station, she is in a seat facing towards the space station. When she hits the button to eject the pod, it launches backwards, and she is thrown back in her seat when this motion would have thrown her forward. (00:04:10)
Continuity mistake: Right after the space station explodes, Dr. Atkins sighs in relief and closes her eyes. She slightly tilts her face down, but still showing her eyes are fully shut. It then cuts to a side angle as the canisters beep before she looks over and her eyes are suddenly open. (00:04:40)
Continuity mistake: During the conversation Nelson is having with Davis about spending more time with animals than people, they are walking out to Davis' jeep and there is a yellow pole attached to the building on the other side of his jeep. The direction of the sunlight is casting a shadow from it on the wall. Nelson and Davis only talk for about 35 seconds, and then the camera pulls back again as Davis begins to drive off and suddenly the shadow from the pole is much longer. (00:12:10 - 00:12:45)
Continuity mistake: When Davis puts a ziplock bag on his hand and picks up the first canister, you can see brown dirt caked onto the sides of it from the ground. Once the girl asks what it is, it cuts to a different angle showing Davis' face before he says he doesn't know. Suddenly in that shot, the dirt has vanished. (00:17:15)
Continuity mistake: Kate fumbles with a couple of coffee cups on the counter and knocks one over. Another she picks up and sets back down, causing the cup holder on it to fall down to its base. She then picks up a white cup with blue lettering as the TV catches her attention. She takes a drink and turns after setting the white cup down. She goes over to the TV and sits, with the camera now showing a view behind her and the counter is visible. Now the cup she knocked over is sitting back up again and the cup holder on the other is back where it was. Also the clear cup with a small amount of red liquid in it disappears in that shot, only to reappear again in a later shot. (00:20:20)
Factual error: When Kate is watching the news, the station on is an LA newscast but showing the code WZPZ. All stations west of the Mississippi river start with K, all that are east start with W. (00:20:45)
Visible crew/equipment: While the team is investigating the space station debris at the wolf crash site, there is a low angle shot. The shadow of the camera is visible on one of the soldiers' feet. (00:21:50)
Character mistake: When George throws one of the soldiers through the cockpit door of the plane, you get a brief glimpse at the pilot and co-pilot, both of which are wearing a Bose headphone/mic set. However the co-pilot has his one backwards, with the mic bent from the right side when it's meant to be on the left. (00:44:50)
Other mistake: Davis tells Kate to go and she jumps out of the falling plane, her chute opening. Davis then takes a minute to free Harvey from the plane as it's still falling before they both get out. Once they are free falling he takes a few seconds before he pulls their chutes as well. However as they are coming down close to the plane crash site, Kate is near level with them in altitude as they are all coming down together. With how high she was when she jumped out compared to the time it took for Davis and Harvey to get out of the plane and open their chutes, she would have been several minutes behind them in the sky, not right next to them. (00:47:45 - 00:49:05)
Suggested correction: She jumped first and would have already descended in altitude. Then the guys jump and freefalled and pulled their chutes so it is plausible they caught up to her altitude when their chutes opened.
Factual error: The B2 can not carry the M.O.A.B. It has to be delivered from a C-130. (01:05:00)
Factual error: When the jet is taking off from Whitman Air Force base in Missouri, there is a mountain range in the background. There are no mountains in that part of Missouri (highest point in Missouri is about 1700 feet). (01:10:30)
Factual error: When the protagonists are able to find the antidote, the doctor rightly slips on a thick rubber glove to take the vial container from a liquid nitrogen cooler (-195.82 °C), and then naively collects the vials with bare fingers, somehow not freezing her fingers off in the process. (01:13:45)
Suggested correction: Maybe it's freezing inside the container which it was in.
Factual error: When the bomber is coming in towards the city about to drop its payload, it is flying in much too low for the bomb it is using. It is shown and stated to be armed with a MOAB explosive, and thus they would have conducted the airstrike from a much much higher altitude to protect the bomber and its crew from its own blast. (01:30:55)
Continuity mistake: Near the end Harvey Russell shows up as George is lying against the building. He notices George has "died" and has his mouth open. The camera angle changes and his mouth is closed. (01:36:20)
Suggested correction: George didn't actually die and was playing dead, but was still slightly moving. Hence why his mouth is closed.
Factual error: When the soldiers are in the woods looking for the wolf, they come across a group a deer that bolt between them and around them scared for their lives and spooked. The deer runs behind the soldiers and they look at each other wondering what happened. Then the giant wolf, Ralph, suddenly comes up from behind the soldiers and eats one. But the deer just ran towards the direction the wolf came from. Meaning the deer got scared, but chose to run towards the giant hungry mutant wolf.
Suggested correction: If you watch carefully, the deer run past them to the right and away from the direction of the camera. Then the wolf comes from right, but from closer to the camera. At the speed that wolf is moving, it was able to circle around them and then strike.