Continuity mistake: It was briefly stated in the second film that the T-Virus was created by Dr. Ashford to cure his daughter Angela and that the Red and White Queens were based on her. This movie contradicts that by suggesting that Dr. Marcus created the T-Virus to cure his daughter Alicia, and that the Red/White Queens were modeled after her. While the rest of the movie stays true to the continuity of the previous films, this rather obvious ret-con is still a major continuity gaff.
Continuity mistake: When the Senator is about to be sacrificed, the cloth on her mouth immediately disappears for a split second. (01:29:35)
Continuity mistake: When Mrs. Otterton is in Chief Bogo's office holding her family photo with both paws, in the wideshots her purse is hanging in the crook of her left arm, but after a brief shot of Judy, when it cuts to Mrs. Otterton's closeup as she tells Bogo about her two beautiful children her purse is gone, then after another brief shot of Judy the purse is back in its place again in the wideshot.
Continuity mistake: Strange is at home, looking for help on a video chat. His friend says no, and in his rage he sweeps almost everything off the table including the Microsoft Surface laptop. Christine enters with food, we cut back, and the area of the table to his left, which was totally clear a second ago, now has several pieces of paper on it and the laptop with a closed lid. A few moments and cuts later, the laptop is in perfect condition on the table with lid open.
Continuity mistake: The doctor starts out carrying a Holland and Holland "Royal" Double Rifle; but when he and Tarzan pursue the train, the doctor loses his H&H rifle in the leap from a cliff. Lo and behold, after they commandeer the train and disembark, the doctor is inexplicably carrying his H&H Double Rifle again. The H&H is not a common rifle, even today, and his chances of just discovering an exact replacement aboard the train is beyond coincidental.
Continuity mistake: In the scene near the end where Ajax has a knife in the side of Deadpool's head and is punching him, later Deadpool pulls the knife out. In a follow up shot there is no hole in the mask where the knife was, but in a later shot the hole is there.
Continuity mistake: When Bodhi Rook is first introduced on Jedha, there is a fallen statue in the sand, first shown lying on its left, but at the end of the scene, the statue is suddenly lying on its right. (00:11:15 - 00:12:15)
Continuity mistake: When April changes into a school girl's outfit to distract Dr. Stockman's assistant, she grabs a miniskirt and ties it around the skirt that she's already wearing. But we never see her take this particular skirt off. It just magically disappears. She is also wearing pantyhose which suddenly changes to over the knee stockings.
Continuity mistake: When the church bell is rehung and struck, it goes from shoulder height to well above head height, then back to shoulder height in subsequent shots. (01:28:15)
Continuity mistake: When Batman goes to save Martha, he pulls the wooden box with his gun and throws it at one bad guy. The guy's head hits the wall, leaving blood. Later on, you still can see the dead guy but there is no blood on the wall any more. The blood appears again when Batman is about to finish off the last person who was stabbed and pinned against the wall. (02:17:30 - 02:18:35)
Continuity mistake: As Captain America arrives in his car at the airport car park, he stops right next to the line dividing the spots. In the following shot, when he steps out, the car is further away from the line, more towards the center of the spot. (01:26:50)
Continuity mistake: When Dylan enters Thaddeus' prison cell and begins looking around, there is a clock on the wall showing 7:52. As Thaddeus walks into the cell seconds later, the time on the clock is suddenly 7:55.
Continuity mistake: Periodically, we see beyond the wall, where it appears to be heavily forested just beyond the wall and a distance beyond. However, once past the wall, the group starts with a cliff down and then it is completely barren, with completely different weather conditions (frequent red rain).
Suggested correction: You're talking about two separate areas. We don't know how far they travelled before coming upon the desolation. The valley was rocky and sparse with trees, but you still see plenty of trees at the edge of the desolation.
Continuity mistake: When the G.R.S. team is on their day off (9/11 anniversary), Tanto is seen video chatting with his wife. In the frontal shot of him, he's using a Samsung smartphone, but in the next shot, it changes to a Blackberry. This is done multiple times throughout the scene.
Continuity mistake: In the beginning, when Jack is talking to the two gangsters, he has his sunglasses on. In one shot, where the camera is behind him, when the two start talking Spanish to each other, you can tell Jack doesn't have his sunglasses on.
Continuity mistake: In the chase scene between the black Dodge Charger and the Police SWAT truck, the damage to the left side of the Charger alternates frequently between damaged and un-damaged.
Continuity mistake: When the helicopter has crashed and the President and Banning are standing outside, Banning removes his radio and earpiece and throws them to the ground. The earpiece is back in the next shot. (00:40:00)
Continuity mistake: When Felicia Williams goes to see Mike at the hotel after the accident, her nails change. During the accident, they are a pink color, but after and in the hotel, they are unpainted. It's unlikely she would have her nails done during and after the accident.
Continuity mistake: At the end of the movie when the mothership takes off the central saucer section is in place, yet we saw the queen alien fly off in it earlier on.
Continuity mistake: In the car-chasing scene with the Jaguar, the pursuer drive three different cars, In real-life they drive BMW e92 M3 coupes, in game-graphic BMW M4 coupes. And that one which crashes right into the Volvo is a BMW e46 coupe. (00:54:00 - 00:56:40)