Continuity mistake: When Miki's husband is killed by the shuriken (large throwing stars), they enter and exit his body vertically (you see them embed themselves into the wall vertically), yet when he falls to pieces, the cuts are all horizontal.
Continuity mistake: At one point, when Leon is fighting with Mahogany on the train, there is a shot of blood dripping off a knife onto Leon's face. This blood later vanishes. (01:20:02 - 01:21:19)
Continuity mistake: When Jessie and Carlos walk to the church ruins, a big bruise on his nose suddenly appears for a couple of seconds, only to disappear briefly after.
Continuity mistake: During the sex scene between Milo Ventimiglia and Lauren Lee Smith, in which the fat guy was found dead, three consecutive shots showed that Milo Ventimiglia has his shirt on on the first, then the shirt disappeared on the next, only to reappear on Milo Ventimiglia's body again in the third shot.
Continuity mistake: The car they pour petrol/gasoline over in the closeup shot is a 2007 Chrysler 300C Hemi with the big square-shaped grille. In the long shot where the car blows up, it is not the same car; the grille has changed shape and is more akin to an old Mercedes.
Suggested correction: The grille hasn't changed shape, it looks different because of the explosion damage.
Continuity mistake: When the "substitute" boy gets off the train he is with an older women. The reporters ask the mom and boy to take a picture together. You can see from the camera angle that the older woman is in the background when the flashes go off taking the picture. Later in the movie, the psychiatrist holds up a newspaper article with the picture in it. In the newspaper picture, the older woman is not in the background.
Continuity mistake: In the scene where Larry The Cable Guy is eating a long dog while talking to Madeleine, he keeps biting down on the bun, yet the eaten part reappears. This happens twice during this scene.
Continuity mistake: When the brothers are standing on the rocks on the beach, the clouds change back and forth behind Stephan.
Continuity mistake: When the boss retrieves the phone from the suitcase, the suitcase between shots if strongly lit all of a sudden. (00:45:20)
Continuity mistake: When King is fighting with Lazarus in the bar, Lazarus gets blood near his mouth like you get when getting hit in the face. But when they fight near the white door, the blood is gone. (01:13:00 - 01:18:00)
Continuity mistake: When the soldiers rip off posters that depicts racial images of buffalo soldiers, the board underneath remains blank. Later in the movie, when they are about to escape the town, the board is shown with tattered old postings again.
Continuity mistake: Mike Manador watches his girlfriend Gina drive away in a taxi. Behind him a truck can be seen coming down the street. Mike then steps out into street seconds later, but the truck has vanished. Next shot looks up the street and sure there is the taxi but no other vehicles, and you can see the entire street. (01:41:25)
Continuity mistake: When the mother puts the drawing from her daughter in her pocket she puts it in the left pocket of her jeans. When she takes it out later, she takes it from her right jean pocket.
Continuity mistake: While on a dirt road, the GPS tells them to turn around when they can. The car then starts to turn left. In the next cut, the car is turning right.
Continuity mistake: 50 Cent goes through the window onto the floor below. There is glass and debris everywhere. Our heroes run past him later and there is no sign of the window debris.
Continuity mistake: When Wyatt is shot, the amount of blood on his shirt next to the collar increases, decreases and even disappears between shots.
Continuity mistake: When we first see Agent Holloway viewing the crime scene photos taped to the wall, he is facing camera looking at transparent pictures on a transparent wall (as if we are behind that wall, seeing through it). When the angle changes to see the Agent from behind, the photos are now paper photos on a normal, opaque wall and the pictures are arranged somewhat differently - most notably to Holloway's right near the top where two wider photos are vertically aligned atop and below each other in the second shot when they were misaligned in the first shot by nearly half their width. The transparency versus opaque materials issue is a stylistic choice of the director and not a mistake, but the mismatched alignments is a mistake. (00:11:25)