Trivia: The sorority mom, Andrea Martin, is also one of the girls in the original "Black Christmas". Her name in the original was Phyllis.
Trivia: The boat that takes George to America, and again back to Africa, is named the H A Rey. This is a tribute to the author of the Curious George children's books.
Trivia: This film was filmed back-to-back with Flags of Our Fathers, a movie from the American perspective of the battle of Iwo Jima.
Trivia: Maya Rudolph, who plays the pregnant character Molly, was actually pregnant during the filming of the movie.
Trivia: The movie which the girl and the baby are watching just before Grant visits them is "The Toxic Avenger" a popular Troma Release.
Trivia: A Wilhelm scream can be heard during the beach volleyball/fighting scene - a henchman is thrown off a balcony and emits one as he falls.
Trivia: The part of the movie where the actor 'Justin' gives his girlfriend 'Nicole' his brother's phone number, listen and have a pen and paper handy. The phone number given is a true Manhattan number complete with area code and full phone number. This is the actual phone number of Jeff Lipsky, the director.
Trivia: Some say that Leroy is experiment 628. Some people haven't noticed that in the episode with 627, at the end of the episode, Jumba had said, "Maybe next time will be better" as he places a pod that said 628. So 628 had already been created. He was never shown in the entire series, though Leroy is 629.
Trivia: Red Dawson has a cameo as the head coach of Morehead State.
Trivia: In the epilogue, all of the characters' fates are accounted for, except for the fact that Noah Dietrich's account of Howard Hughes' life, which formed the "rough draft" of Clifford Irving's hoax, WAS published (presumably after considerable editing) as a mass-market paperback after the scandal struck.
Trivia: Abigail Breslin, who plays Trish the elf girl, is the younger sister of Spencer Breslin, who plays Curtis.
Trivia: Actress Amy Adams makes a small cameo during the "Master Exploder" sequence. She is the woman who mouths "I love you!" to Jack Black, and is subsequently covered with the brains of the man whose head explodes.
Trivia: Matt Damon is only eleven years older than Eddie Redmayne, who plays his on-screen son.
Trivia: The child-actor playing young Selene is actually the daughter of adult Selene's actress Kate Beckinsale.
Trivia: The four customers who are seated behind Sheryl and Richard during the diner scene are the parents of the movie's directors Jonathan Dayton and Valerie Faris.
Trivia: Marilyn Dean tells Brooke (Jennifer Aniston) to go see her personal waxer at the spa and to ask for the "Telly Savalas". Telly Savalas was Jennifer Aniston's godfather. (00:56:00)
Trivia: As a bit of an easter-egg, Mel Gibson included a single-frame of an actor dressed as Wally/Waldo from the "Where's Wally/Waldo?" book series in the theatrical version of the film. It was reportedly seen as being in poor taste, so it was removed from the initial DVD release. However, he was allegedly added back into the film for the Blu-Ray release.
Trivia: At Frankie's house, when some girls visit during the daytime, Frankie turns to Zack and calls him 'Yankele'. Yankele is a Yiddish [German-Hebrew] affectionate version for Yaakov, or Jacob, since Zack is Jewish.