Continuity mistake: When the red Sunbird and the Caddy are driving sown the steep hill, the windshield on the Sunbird changes from passenger side busted out, to completely gone, to completely intact, when they hit the tree at the bottom. (01:18:15)
Continuity mistake: When Peter is just getting to the science lab at the beginning right after his friend gets out of his fancy car, if you look at the extras walking behind the two, you will see a bright red haired girl walking by, going towards the building, but when the camera focuses on Peter the girl is there again, walking the opposite way on the other side of the huge sidewalk. You see her about 5 times going back and forth to the building. The first few times she's alone, then she's walking with another girl. (00:05:55)
Continuity mistake: When Marlon Brando is gunned down at the fruit stand, he drops the bag of fruit he just bought. However, when he's collapsing against the car, the bag of fruit is now on the hood of the car. (00:43:05)
Continuity mistake: As the FBI and Richard Gere rush to the hospital to save the First Lady they are flying in a helicopter. You see a shot of the helicopter flying over buildings then it cuts to dialogue inside then back to the landscape shot. However in the first shot the helicopter carries the number "28" on the side. When it cuts back after the dialogue it has "29" on the side of it. (01:36:35 - 01:40:00)
Continuity mistake: In the scene where John commits suicide by slitting his wrist, the soles of his shoes go from brand new and unmarked (quite clearly seen in a couple of close up shots) to scuffed and worn (also seen quite well in a couple of shots). (01:34:25)
Continuity mistake: After Stark is paralysed and slightly recovers, he goes to get his energy. Right then the blood around his left ear has vanished. Being seconds away from dying, the last thing he would think of is taking a shower.
Continuity mistake: When M meets Bond near the beginning of the film, as she walks down the stairs she is wearing flat shoes, but as she gets to the bottom she is wearing high heels. (00:16:45)
Continuity mistake: When Nicolas Cage drives through the window in the yellow Ferrari and the shot changes, he is coming out from a different window than in the first shot. In the first shot he emerges from the window to the left of the 7th Street Garage storefront ('Classic Autos' written on the window), but next shot he emerges from the window to the storefront's right. Also, note the now glassless window to the storefront's left, due to a previous take.
Continuity mistake: When the girls figure out that Knox is after Charlie, and Dylan thinks of the picture and they zoom in onto "Townsend." The shot before the final shot of the photograph shows Knox's father's arm around Charlie, when in all the other shots, he has his arms above his head. (01:00:05)
Continuity mistake: When Adam pounds on Zep with the toilet seat, he grabs his shoulder in pain. In the first shot of him holding his shoulder, his hand is soaked in blood. In the second shot, however, his hand is much cleaner. (01:30:25)
Continuity mistake: When Maya enters Peter's office for the first time, you can see that he had just written something on his laptop. While they talk, you can see the word-program on the computer screen: it shows one page. Cut to Maya, then back to Peter: it shows two pages. Another cut: one page. This happens two or three times throughout the scene. (00:29:30)
Continuity mistake: In the opening scenes where the are driving home and the right front tire goes flat. Just before the Big rig truck hits them you can see that the tire is not flat. (00:07:50)
Continuity mistake: When Snake kills the wrestler he falls forward shoulders forward, next minute his arms are over the ropes, next minute his arms are in a different position again - quite active for a dead man. (01:16:55 - 01:18:10)
Visible crew/equipment: When the guy on the roof stands and takes aim at the window in preparation for Brian, the film crew are reflected in a window behind him. (00:13:00)
Continuity mistake: When one of the stormtroopers unties Han Solo before he is put into the carbonite, watch his wardrobe - he has a disappearing / reappearing jacket on. This is fixed to an extent on the DVD - the jacket is now lightened to almost match his shirt, but it's still shiny like leather. (01:32:05)
Suggested correction: It just looks like a jacket because it's a shadow.
Other mistake: At the end, when Peter saves Mary Jane from the collapsing structure, he jumps up in the air and swings her to safety. However if you look at the web he is holding onto it is hanging down vertically. What did he attach the web to that was directly above him, the sky? Every bit of the structure around him was/had collapsed and the only thing remotely close to swing from was the cranes. Yet we see that was quite a distance away, so Peter would have had to shoot the web away from himself not above him. (01:47:50)
Continuity mistake: When they bring Marvin Nash to be tortured, his hands are cuffed behind his back. They start kicking him and his hands are then seen cuffed in front. Then, they switch back just a few moments later and his hands are back behind his back again.
Continuity mistake: There are a couple of instances in the movie where the models do not correspond with the actual sets. When Klytus arrives at the Hawkmen city he lands near the top of the city. Yet in that very hall there is a pit with a deep void underneath. Such a room could only exist at the bottom of the city. Also, when the Hawkmen start to land on Ajax, its engine section appears to be missing. (01:10:10 - 01:14:30)
Revealing mistake: When Santos catches fire and falls over on deck, the fireproof vest is very visible on his right arm. (00:46:05)
Continuity mistake: When Tyler gets beaten up by Lou, his mouth is bleeding after the first punch. After maybe two punches Tyler jokingly claims to "get it", then he says he "lost it". Right then the blood is no longer there. (01:12:25)