Character mistake: In the start of the film, the sticker on Peter's head for his work misspells the word Bleecker Street on it.
Plot hole: Harry tells Doc Ock that in order to find Spider-Man he must find Peter first. Doc Ock finds Peter with Mary Jane in the cafe and throws a car through the window straight at them, then later throws Peter against a brick wall. Any normal person would've been killed instantly (or very badly injured), and Doc Ock doesn't yet know that Peter is Spider-Man. Given that Peter is his only lead on Spider-Man, it makes no sense that Doc Ock would try to kill him.
Suggested correction: Doc Ock is being controlled by the arms. They aren't behaving rationally.
Creating a series of silly explanations for obvious plot holes never resolves them. These arms were not behaving irrationally. In many scenes they were shown to be very intelligent. A good example is the scene where they attack doctors who try to remove them from Doc Ock's body. Saying that they weren't behaving rationally is absurd.
He may not have been trying to kill Peter, he could've been trying to make more of a scene of his entry, so Peter would take him more seriously and tell him where Spider-Man was. He could've been thinking of it as a risk of killing Peter though, but his arms made him go crazy.
This is only a theory. Theories never resolve mistakes.
It's not a theory. When Otto is first giving his demonstration to everybody at his apartment, a woman asks if the advanced AI for the tentacles would make him susceptible to being controlled. Otto says that yes it would so he shows everybody the inhibitor chip that he designed so he would not fall under its control. After the inhibitor chip gets destroyed, it's seen that the tentacles have not only taken control of his mind by forcing him to commit crimes, but have slowly driven him insane.
This scene is much too confusing for many people. This entry is correct. This is a mistake.
If these tentacles wanted him to finish the experiment then they wouldn't make him kill the person who has valuable information for him.
The arms are influencing his thoughts but not controlling every part of him. Doc Ock still seems to have control when defending himself but they seem to work in tandem with Ock. The only time they work on their own is when he under anesthetic. As we don't see him before he throws the car, we can only speculate the arms were trying to hurt Peter by themselves.
It's a cool scene regardless man.
Killing Peter would probably send a message to Spider-Man as well, so Ock probably wasn't concerned about being gentle.
Continuity mistake: During the train scene, Spider-Man's mask had gone partially black. We also see it when Spidey puts his mask back on. Yet when Doc brings him to Harry, we don't even see a patch of darkness on his mask.
Factual error: Considering the brightness of the fusion process, Dr. Octavius has to wear special goggles to be able to see it. Yet no one else in the room is wearing such goggles or seem hurt by watching the whole process, just as at the end of the movie. When welding something, no one can look at the arc that's created, as it would hurt his eyes and burn his retina; presumably, the fusion process would be brighter and more powerful than that, and so should have some kind of damaging effect on everyone's eyesight (except Spider Man's, maybe).
Visible crew/equipment: On the way to the theater Peter intercepts a police officer chasing a couple of criminals. At the end of that scene one of the police cars has a tremendous wreck that swings the car sideways. There is a clear shot of the driver with a black helmet on.
Continuity mistake: When Dr. Octopus is robbing the bank, NYPD squad car 4619 arrives on the scene. However, squad car 4619 was badly damaged during the pizza delivery car chase earlier in the movie - an awfully quick fix. (00:24:55 - 00:49:45)
Continuity mistake: After Spider-Man recovers from the train incident, Doc Ock smashes in the other end of the train and throws the door on the floor in front of him. The camera cuts to another shot, and when it returns the door is no longer on the floor, nor is it there for any subsequent shot.
Continuity mistake: When Peter misses the class at the university, the way he holds his books/folders changes when the teacher talks to him.
Continuity mistake: Peter has a small horseshoe-shaped scar on his right cheek. In Dr. Octopus's lab, as Octopus is destroying the fusion reactor, they share a meaningful look and the scar has switched cheeks. (00:26:15 - 01:46:15)
Continuity mistake: When Aunt May hugs Peter near her "hero" speech, she hugs him with her head to his left shoulder. The shot changes and you see that she is now on Peter's right shoulder. The shot changes back and you see her on his left shoulder again.
Factual error: Dr. Octavius says his fusion relies on tritium and that there is only 25 pounds of the substance in the world. In reality, tritium is a good deal more common than that. From this article (http://www.epa.gov/radiation/radionuclides/tritium.htm): "It is used in various self-luminescent devices, such as exit signs in buildings, aircraft dials, gauges, luminous paints, and wristwatches. Tritium is also used in life science research, and in studies investigating the safety of potential new drugs." There's also a large region of water near Antarctica which is rich in tritium.
Suggested correction: According to the link provided, as well as Wikipedia (and its resources), Tritium is actually quite rare on Earth, and uncommon in natural sources.
The link provided said that tritium "is produced naturally in the upper atmosphere when cosmic rays strike atmospheric gases. Tritium can also be produced by man during nuclear weapon explosions, in reactors intended to produce tritium for nuclear weapons, and by reactors producing electricity." https://trainex.org/web_courses/tritium/reference_pages/tritium%20EPA.pdf.
Continuity mistake: When Aunt May is falling off the building, her purse is on her right arm. The next shot shows the purse on her left arm. (00:52:05)
Revealing mistake: In the scene where Peter saves the child (Venus Lam) from the burning building, right after the jump over the floor opening, the child stands up to help Peter we can see she wears knee pads under her pajamas.
Visible crew/equipment: In the very last scene of Mary Jane looking over the city in Peter's apartment, there is a reflection in the window where the camera lens and cameraman are partially visible.
Plot hole: Dr Octo builds a new, bigger machine and it starts to pull the building in on itself, but it's so strong it also manages to pull all the metal from the streets as well, including cars. When Spiderman saves MJ, the metal cranes have somehow managed not to be pulled in or at least bent by this massive machine that made a building collapse on itself.
Continuity mistake: Regarding the scene where Doc Ock has delivered Spider-Man to Harry's mansion, when Harry pulls off Spider-Man's mask, there is a very obvious and bad splice. The "mask on" Spidey's head is in a different position and further away than the "mask off" Spidey's head.
Continuity mistake: During the final conversation between Spider-Man and Doc Ock, the rips in Spider-Man's suit keep changing. For instance, there is a tear on his right shoulder; for most of the scene, there is a single piece of black webbing left holding the rip together, but when Doc Ock grabs Spider-Man's arm, the rip now has two pieces of black webbing. Then it goes back to one.
Continuity mistake: In the scene where Peter is riding his scooter to Mary Jane's play, after the music fades out you see a black convertible being chased by several police cars. The black convertible is rammed forcibly, and you see many hideous dents on the side of the car. Thirty seconds later, after Peter is done talking to the kids, we see the same car from the same side it got rammed into, but the hideous dents have vanished. (00:24:25)
Other mistake: At the end, when Peter saves Mary Jane from the collapsing structure, he jumps up in the air and swings her to safety. However if you look at the web he is holding onto it is hanging down vertically. What did he attach the web to that was directly above him, the sky? Every bit of the structure around him was/had collapsed and the only thing remotely close to swing from was the cranes. Yet we see that was quite a distance away, so Peter would have had to shoot the web away from himself not above him. (01:47:50)
Continuity mistake: As Peter stops the elevated train with many webs, a tear appears in his suit on the inside left arm during a closeup. Later, when his arms are still outstreched, there are many shots where you can see that the tear has disappeared; for example, a few shots later when he is still trying to stop the train; when the passengers are lifting him over their heads into the train; and many others.