Character mistake: Lestrade mentions that there could be some "poor sod covered with semtex on the streets somewhere" when talking about Moriarty's victims, but semtex does not go off via gunshot, much like C4. But that is what happens when one of the victims dies however, so the explosives are not semtex.
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Suggested correction: The term "Semtex" is often used to refer to any plastic explosives, much like the term "Hoover" for a vacuum cleaner or "Kleenex" for a tissue.
But that doesn't negate the mistake.
