Continuity mistake: The Monarch has a massive tattoo on his back which not present afterwards.
Suggested correction: In the same episode he's shown in the shower washing it off. It was temporary and a nod to the movie Red Dragon.
Continuity mistake: Colonel Gathers says to Brock Samson, "You're not in the Marines anymore." But in the earlier episode, "Past Tense," after the credits, there is a flashback to college again and Brock says, "I'm off to join the Army"
Continuity mistake: When the pirate captain gets shot in the arm with the tranq dart, both the dart and tourniquet change locations on his arm every cut. Even which one is higher up on his arm swaps. (00:11:17)
Continuity mistake: At the Guild underground club, when Dr. Venture and Quizboy are on the wheel of torture, they switch position relative to the various torture methods when the camera zooms in, even though the outer ring and center spin together. For example you see Quizboy's head under "Rail Reaper", but then it's under "Burnt Slumber" and later "McPain's Anguish."