Continuity mistake: Avery and Kepner are at the bar. Keep looking between them (over Kepner's left shoulder). Right when Kepner says "I'm a soldier" a guy in in the background comes around the corner wearing a dark shirt with what looks like a red vest/sweater. The camera changes to a different angle for Avery's line, and then when it comes back to Kepner for her next line, the guy in the red sweater/vest comes around the corner again. (00:16:00)
Continuity mistake: Dixon is upset and rushes off. Bailey follows her into a room to calm her down. When Bailey enters we hear the sound of Bailey closing the door. In the next shot from Dixon's perspective the door is ajar 1-2 inches. Then the next shot from that angle the door is suddenly fully closed. (00:26:00)
Continuity mistake: In the scene between Preston Burke and Cristina Yang in the locker room, Dr. Burke walks in wearing a brown jacket. During the first shot the collar of his jacket is lying flat. After he starts talking, the collar is sticking up in the back. After he says "I know you," the shot zooms out and his collar is lying flat again. When he says "I know you" the second time, it is sticking up again until the scene ends. (00:27:30 - 00:28:30)
Band Aid Covers the Bullet Hole - S2-E21
Continuity mistake: The way the patient holds the ice pack over his crotch changes between the wide and close-up angles.
Band Aid Covers the Bullet Hole - S2-E21
Continuity mistake: During the credits, the baby's head keeps swapping from covered to uncovered.
Continuity mistake: When Addison introduces herself to Meredith, she reaches out to shake Meredith's hand twice.
Continuity mistake: When Derek is explaining to his patient about the risks of the brain surgery operation, Derek's hands move from his coat pockets to up near his chest, and back to his pockets. (00:30:40)
Band Aid Covers the Bullet Hole - S2-E21
Continuity mistake: When Derek is talking to Meredith on the hospital balcony and they are eating a sandwich each, in one shot Derek is taking a bite from his sandwich, then in the next shot he is suddenly holding it down at waist level. He then raises it to take another bite and you can see the previous bite has gone and the sandwich is whole again. (00:21:55)
Continuity mistake: Just before George withdraws some blood from Bex's arm, her right sleeve is rolled up when Addison is beside her talking. In the next shot as Bex is drawing, the sleeve is suddenly rolled back down and George pulls it back up again to get some blood.
Owner of a Lonely Heart - S2-E11
Continuity mistake: When Dr. O'Malley is talking with Carl Murphy in his room, the position of the circle of containers (with the leeches inside them) changes between the shots during the scene. (00:32:10)
Owner of a Lonely Heart - S2-E11
Visible crew/equipment: When Burke hands Cristina the cup of coffee as she leaves for the hospital, blue screens can be seen in his eyeglasses.
Thanks for the Memories - S2-E9
Continuity mistake: When Holden is talking to Meredith about whether he wants the surgery or not, his hand is on this chest, then isn't, then is again. (00:28:10)
Continuity mistake: When Alex and George are trying to get out of the elevator that they are stuck in, watch the monitor screen attached to the gunshot victim. The lines on the monitor keep instantly changing appearance (from straight, to jagged, and then back, etc.), especially the middle blue line. (00:13:05)
Continuity mistake: When Meredith, Christina and Izzy are standing by the hospital hall balcony talking, the nurse, doctor and patient extras walking and passing in the background are inconsistent from shot to shot. In addition, the position of the three ladies arms / hands on the banister keeps changing during this scene. (00:12:35)
Continuity mistake: When Alex walks over to the desk that Derek is sitting behind, with the couple arguing in the background, there is a box of tissues with a tissue pulled so that it is almost out. In the next shot the tissue is barely out of the box. (00:26:20)
Continuity mistake: When Addison shows up at the end of the episode, the umbrella she holds keeps changing position and swapping hands between shots. (00:42:05)
Continuity mistake: Izzy tells the male patient she is a good doctor even though she was a model. Her hair is parted to the left and in the next shot it is parted to the right.
Other mistake: The exact same shot of Derek's radio tuner is used twice-once when he calls Amelia and again when he gets in the car after helping at the accident. Both times, the clock says 7:45PM, but Alana (the AP class taking, cello playing student) says that she's supposed to be at school, implying it's sometime between 8AM-ish and 3PM-ish. Also, the sun sets around 7:30PM in Seattle on March 26, but it is obviously day time for the duration of this scene so there's no way it could be 7:45PM in either of the shots in which the clock is shown. (00:03:30 - 00:18:40)