Factual error: Linc arrives at the 'Bolshoi Booze' location at 17:45. It is an 8 hour drive from Trinidad Colorado to that location, which is right on the Texas - New Mexico border. That means that they would have had to have left at 09:45 that morning. But they don't appear to have stayed a night at Linc's father's place - and in none of the other plot lines has it been night. They couldn't have covered that ground in the time span of the plot.
Continuity mistake: When Sara is being tortured in the bathtub Paul Kellerman receives a call. When we see a brief clip of Sara, her hair is a lot drier than it was a second earlier.
Continuity mistake: The positions of the coolers the clerk falls into changes between shots. Note the colours of them. (00:02:40)
Visible crew/equipment: Just as Alex works out of the numbers, the shot changes to Michael. In the closeup of his face, a white reflector screen is visible in his sunglasses. (00:20:30)
Visible crew/equipment: When Michael gets out of the red truck in the desert, the silver wing mirror reflects a black object that is at the exact angle of the camera shot. (00:14:05)
Continuity mistake: When Bill lets Mahone out of the cage he's in, Bill has his left hand above the latch in one shot and not in the next. (00:16:25)
Continuity mistake: When Michael knocks the clerk to the floor, his head is next to 2 coolers. When the camera changes a shelving unit has appeared. (00:02:30)
Continuity mistake: When Sarah is being tortured at the end, her hair is constantly changing position. (00:40:00)
Continuity mistake: In the hardware store, the box with the vials in keeps changing from open to closed. (00:01:50)