Now You Know - S4-E1
Continuity mistake: When Bree grabs the old lady's wrist to keep her from touching her belly, her thumb is on the palm side of the lady's wrist. Then when the shot changes, Bree's thumb is now on the back side of the lady's wrist.
Answer: Kayla was sent away in episode 16 (The Gun Song) in season 4, after falsely accusing Lynette of child abuse. She now lives with her grandparents - probably Nora's parents.
I'm curious why we never see her again, why she never talked about, and why Tom never mentions visiting her.