Plot hole: Rex is in the hospital for having a minor heart attack and is awaiting surgery to receive a pacemaker. 1) He isn't connected to an ECG or any other heart monitor so no one is aware of his heart attack. 2) They ran blood tests and checked his potassium levels. They would have also checked the concentration of his medication in his blood. (This should have been done earlier in the season too when they first discovered his medications were not working.) Zero concentration of medication in his blood could throw suspicions on his wife just as easily intentionally giving him potassium.

Desperate Housewives (2004)
1 plot hole in One Wonderful Day - chronological order
Plot hole: When Zach Young's grandfather died, Zach was said to be the sole heir of the fortune. However, Noah Taylor (the grandfather) had a daughter that appeared several times while Mike Delfino was looking for Deirdre. Where was Kendra Taylor while Zachary Young was spending Noah's fortune on dresses for Gabrielle Solis? Why didn't she claim her share? She simply disappeared.
Bree Van De Kamp: It's the age-old question, isn't it? How much do we really want to know about our neighbours?
Trivia: Across Season 4: Two Lois Lanes appear together in this season: Teri Hatcher played Lois Lane in The Adventures of Lois and Clark and Dana Delaney voiced Lois Lane in Superman: The Animated Series and its follow-ups.
Question: Where did Kayla go? When did they get rid of her and where did she go? And which episode is it?
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Answer: Kayla was sent away in episode 16 (The Gun Song) in season 4, after falsely accusing Lynette of child abuse. She now lives with her grandparents - probably Nora's parents.
I'm curious why we never see her again, why she never talked about, and why Tom never mentions visiting her.