Plot hole: Rex is in the hospital for having a minor heart attack and is awaiting surgery to receive a pacemaker. 1) He isn't connected to an ECG or any other heart monitor so no one is aware of his heart attack. 2) They ran blood tests and checked his potassium levels. They would have also checked the concentration of his medication in his blood. (This should have been done earlier in the season too when they first discovered his medications were not working.) Zero concentration of medication in his blood could throw suspicions on his wife just as easily intentionally giving him potassium.
Desperate Housewives (2004)
1 plot hole in One Wonderful Day - chronological order
Other mistake: Throughout the sixth season Eddie Orlofsky attends school with Porter Scavo, and Danny Bolen, witch means they must be close in age. However, in season 6 episode 20, it is revealed that Eddie was in high school the same time as Danielle. This does not make sense due to the fact that while Danielle was in high school, Porter and Preston were about 10.
Carlos: You know who you are, Gaby? You're the kind of person who would have turned away Mary and Joseph from the inn.
Gabrielle: Well, they should have called ahead.
Trivia: Across Season 4: Two Lois Lanes appear together in this season: Teri Hatcher played Lois Lane in The Adventures of Lois and Clark and Dana Delaney voiced Lois Lane in Superman: The Animated Series and its follow-ups.
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Answer: He was investigating the lead not the case.