Continuity mistake: When Peter enters the cockpit and accidentally kills the pilots the cockpit looks small enough so that it could only fit Peter and the pilots in their seats. However, when he turns around to leave the cockpit looks big enough to fit an entire group of people.
Continuity mistake: When Karen Black is first shown, her blue uniform is sleeveless, showing her white shirtsleeves. After a cut to the "Dawson's Creek" kids, Peter says "It was a movie in the seventies," and Black's outfit has sleeves. Later, when she is helping people off the plane, her uniform once again is sleeveless.
Continuity mistake: When Peter is on the phone talking to Death the color of the napkin on the table changes from red to a brownish color.
Continuity mistake: When Death is talking about how he wanted to be a wood nymph, he has no pillows, but in the next shot, he has a blue pillow.
Continuity mistake: When Stewie shoots the darts at Lois through the straw they get stuck to the cupboard door but in the next shot they are gone.
Continuity mistake: In the 'Titanic' spoof, just as Jack says "Yeah, about that, I was pretty sure I was gonna die", his head and body change distinctly between shots. (00:16:25)
Continuity mistake: When Death is incapacitated and Peter is wearing the Death cloak, the stool that Death's legs are resting upon changes from having purple to brown legs. (00:16:45)
Continuity mistake: During the yard sale, Lois goes outside the house but she doesn't close the door. She talks to Peter and the shot later, the door is closed.
Continuity mistake: Death has the TV remote asking how old the TV is. As Lois talks, he puts it down, then it suddenly disappears altogether.
Continuity mistake: As Quagmire and Cleveland are talking to Peter, the hat Cleveland is wearing disappears and reappears between cuts.