Continuity mistake: When we first see Kate and her parents at the restaurant there are only 2 empty chairs. Stewie then sits in the chair next to Kate. After Kate's parents ask what happened, we see a chair in between Stewie and Kate, but you can also see the edge of third empty chair. A plate and the wine filled glass also move.
Screams of Silence: The Story of Brenda Q - S10-E3
Continuity mistake: When Lois and Brenda are out eating, Lois closes her menu when the waiter comes by. But the next shot of her menu it's open when we don't see her touch it.
Seahorse Seashell Party - S10-E2
Continuity mistake: Brian cuts his entire ear off. The top of his ear reappears a few shots later.
Screams of Silence: The Story of Brenda Q - S10-E3
Continuity mistake: When Brenda arrives at her intervention, she sits down and puts her purse on the floor. It disappears for the rest of the scene.
Screams of Silence: The Story of Brenda Q - S10-E3
Continuity mistake: Throughout the entire intervention scene you can see Brenda's hands. After her boyfriend starts talking he says they are getting married. Brenda holds up her hand to show her ring and suddenly there's a splint on her finger.
Continuity mistake: When Brian is with Stewie asking for help, we see a set of blocks on the table, including a set of 3 stacked up. In the next shot, the 3 blocks vanish.
Continuity mistake: Kevin takes his jacket off at the dinner table. His shirt says Ed Hardy. The name wasn't on the shirt until he took his jacket off and it disappears again when he puts the jacket back on.
Stewie Goes for a Drive - S10-E4
Continuity mistake: Stewie packs his backpack, opens the window and slides down the drain pipe. When Brian comes in to get him, the window is closed, but Stewie didn't do it.
Screams of Silence: The Story of Brenda Q - S10-E3
Continuity mistake: When Peter and Joe find Quagmire hanging from the ceiling, he has 2 black eyes. Minutes later in the hospital, they look normal.
Continuity mistake: In the scene with the multiple versions of Stewie and Brian come back to 1999, one Peter is with one of them. When Stewie asks everyone to vote between 9/11, Peter is standing in the foreground, but disappears when one of the Stewies says Brian had his throat slit. (00:18:25)
Continuity mistake: When Peter (from 1999) arrives at Quagmire's house for the stag party, the window is small. But in the next shot when Brian looks through the window, it is a lot bigger. (00:05:55)
Continuity mistake: Quagmire and Meg are sitting on the couch. From out of nowhere he gives Meg a gift for her birthday. He came over empty handed.
Continuity mistake: Near the end of the episode, Joe and Quagmire are shown sitting at a booth inside the bar with Joe pulled up to the corner of the booth. As Peter apologizes to them, Joe is no longer seen next to him. As Peter takes Quagmire's check, a part of Joe is seen sitting in the next booth. In the shot after, he disappears again for the rest of the scene.