Continuity mistake: When Mr. Burns and Smithers go to leave, the beak-like knocker has disappeared from the Simpsons' front door.
Continuity mistake: When Marge goes in front of her painting after it is uncovered she stops with her head in front of Mr. Burns' genital area. In the next shot, her head is shown in front of Mr. Burns' hand.
Continuity mistake: In the scene where Bart and Homer find Marge's paintings in the attic, there is a shot of the paintings all stacked up and you can see that the edges of all of them are the same shade of pink as The Front painting. However, when the boys flick through the paintings, the backgrounds and edges are a variety of colours, including pale blue.
Continuity mistake: After Lisa paces around the school hallway practising how to ask Mr. Bergstrom over for dinner, when she opens the classroom door there's a backplate behind the doorknob and a lower panel under the window, but when she sees Miss Hoover and gasps, the backplate and lower panel have both disappeared. (00:13:35)
Continuity mistake: When Lisa opens the classroom door (opposite the teacher's desk) and is shocked to see Miss Hoover has returned, note the door opens outward (into the hallway) and the doorknob is on the right side of the door. When Lisa runs out of the classroom, that door now opens inward and the doorknob is on the left side of the door. (00:13:40)
Continuity mistake: When Miss Hoover returns to class she writes "psychosomatic" on the blackboard, but when Lisa runs out of class the word has vanished from the board. (00:13:55)
The War of the Simpsons - S2-E20
Continuity mistake: When Homer has caught General Sherman he beats it with an oar so that the oar snaps in two. Then suddenly Homer rows with both oars intact.
Three Men and a Comic Book - S2-E21
Continuity mistake: When Martin is tied to the chair near the end of the episode, the number of ropes tied to him change from four, then to three, and then back to four.
Three Men and a Comic Book - S2-E21
Continuity mistake: When Martin is tied up in the treehouse, at one point Bart takes the brick off the comic book and sets it down near Martin. When Bart and Millhouse fight, the brick disappears.
Three Men and a Comic Book - S2-E21
Continuity mistake: When Bart, Martin and Milhouse start to fight, the Radioactiveman issue 1 that they were protecting has disappeared from the table. Then when Marge brings up some food, they all start eating. The table has disappeared altogether.
Three Men and a Comic Book - S2-E21
Continuity mistake: When there is a rotating shot of Bart, Martin and Milhouse up in the treehouse, the shot never goes past the table, even though it should.
Blood Feud - S2-E22
Continuity mistake: When Mr. Burns gets up after the blood transfusion, Dr. Hibbert is incorrectly colored yellow instead of brown.
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer