Continuity mistake: Just before Marge tries to sell Skinner the tie rack, she is writing on something. She then puts her hands down by her waist, and then brings one up to turn it on and both up to pull the motor out. The point is that the pencil and the item she had in her hands have simply vanished, and we never saw her put them down either.
Continuity mistake: When George and Homer burst out of the manhole, there is a shot of the Simpsons' house covered in mud, then a quick one of it totally clean, then another when it's muddy again.
Continuity mistake: When Bart is looking for candy in the cupboards, the wine bottles in the nearby rack change position between shots.
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer