Continuity mistake: Smithers opens the second case for Tom Jones as the green gas has all but dissipated from the case. When the shot changes, there is still gas coming from the case. The remaining gas also changes place in the vicinity of the case. (00:15:50)
Continuity mistake: When Tom Jones walks off-stage a towel appears around his neck instantly between instant camera cuts. (00:16:00)
Continuity mistake: When Burns is lay on the floor telling Smithers that he dreamed of Marge again last night, the painting behind Smithers is very badly painted and very childish in appearance. Burns' head is completely disproportionate for example. When the shot changes to Smithers the painting is now a lot more detailed and no longer looks childish. (00:14:42)
Continuity mistake: When we see Smither daydreaming about Mr Burns coming in through his window at night, the painting on the wall disappears between shots. (00:14:50)
Continuity mistake: During the musical number about Mr. Burns, Homer and Marge swap sides of the table. (00:05:40)
Revealing mistake: At the start when we see stuff falling off the roof, the animation for the swings in the background simply fade out and are incomplete. (00:02:05)
Revealing mistake: When Homer points at the donut guy, his right shirt cuff is colored yellow. (00:12:50)
Other mistake: When Homer pretends to read the newspaper, the back page is very noticeably blank and missing any print. (00:08:00)
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer