Paradise on Your Doorstep - S1-E5
Factual error: The plane Tom hijacks is a Grumman Goose. This has a maximum altitude of around 20,000 ft. When the pilot flips the pressurisation switch, the instrument panel shows the plane is only at 2500 feet! The cabin wouldn't have depressurised at such a low altitude - and even had it done so if the plane had been flying much higher, it wouldn't have had such a severe and debilitating effect so quickly on Tom as suggested in the episode - he passes out in about 3 seconds.