Continuity mistake: When the guys take off to Bangkok on their direct flight, the plane is a 4 engine jet. When they land, it's a 2 engine jet.
Factual error: The protagonists travel to the wedding resort at Krabi on Thailand's West coast from Bangkok by speedboat in a relatively short time. To travel from Bangkok to Krabi by sea would involve a 1,500 mile journey through the straits of Malacca via Singapore and would have taken them at least 48 hours, non stop, with additional fuel onboard.
Continuity mistake: When Phil, Alan and Stu are sat in the diner near the start of the movie, the amount of orange juice in Phil's glass changes between shots, even though Phil doesn't drink from it once.
Continuity mistake: When Alan is at the hospital eating a watermelon, there are dribble stains on his lap. When he goes outside his pants are dry.
Visible crew/equipment: When the crew arrives in Bangkok in the white cars, you can see a stage light in their reflections.
Continuity mistake: When Alan is walking through the airport, his ticket and pipe keep switching between hands.
Continuity mistake: At the end of the movie when Mike Tyson is about to sing, in the first few seconds before Mike comes out, the lead singer holds up his guitar in one hand. When the camera angle changes to show Mike popping out, the singer is already playing his guitar. Also, at the end of the song, when the four dancers are going back to their positions at the beginning of the movie, they are almost at their spots, but when the angle changes, they are all entirely there.
Continuity mistake: When the Russian gives a piece of banana as a reward to the drug-dealing monkey; the banana skin is removed. However when shown eating the banana on the balcony, the banana skin is attached.
Continuity mistake: In the scene at the riverside cafe, a tugboat slowly pushing a long string of barges is seen in the background. In subsequent shots looking in the direction of travel, the tugboat and barges have disappeared but there was not enough time for them to have traveled out of view.
Continuity mistake: When Stu is on top of Alan while they are fighting, Alan's hat shifts too fast between in and out of his head between shots.
Factual error: When the guys are at the airport in California it's daylight outside with their flight being at 3:15 pm. Given the time difference between California and Thailand and the flight being 16-17 hours it would be about 10-11 PM the next day in Thailand. It would not be light outside when they landed like the movie shows.
Continuity mistake: When Alan leaves the monkeys outside the vet's place and runs to the car, the damage on the right side of the car besides the trunk appears from nowhere.
Continuity mistake: When Chow and the others are getting away from the drug dealers in the silver car, they hit a pig which stains the right side with blood. A few shots later the blood is gone.
Continuity mistake: When Phil, Alan and Stu are talking with the policeman in the restaurant the sun on the table changes between shots.
Continuity mistake: When Stu and Alan are fighting on the street the sun changes between shots.
Continuity mistake: In the scene were Phil was shot, he falls to the ground and his shirt is completely covered with dirt on the back. But when he is leaving the hospital, the shirt is completely clean on the back. It's got a bullet hole in the sleeve, so it's the same shirt.