Mission to Mars

Plot hole: When Tim Robbins is floating away in space his wife could have easily saved him. She could go out a little further, use the grappler to catch her husband, then use the fuel she has remaining to halt their acceleration towards the planet and return them partway to the necessary orbital altitude/velocity to rendezvous with the resupply module. Then, Gary Sinise could come out partway to them using his thrusters, Connie could shoot the grappler out to him, and he could reel both Connie and Tim Robbins back in to the resupply module.

Factual error: Their complete and utter disregard for the most basic scientific facts in this movie is amazing. It's already been said that Gary Sinise couldn't possibly have recognised the DNA sequence as human (that segment may have been enough to produce a single protein common to any lifeform). The thing that gets me is that he recognises that the DNA is missing a couple of "chromosomes" to complete it. DNA is made of units called nucleotides (remember A,T,C,& G?); chromosomes are formed by huge strings of DNA wound together (not the other way around). You don't need a degree in Biology to know this, you just need to have stayed awake in high school.

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