Continuity mistake: The computer terminal used by Don Cheadle's character has a grey cable connected but the connector appears damaged - twisted out of alignment. A few seconds later the same cable appears connected normally then, a few seconds after that, it is damaged again. (01:13:00)
Continuity mistake: At the moment where you can see Gary Sinise is standing in the white surroundings filling up with water (he's going to be drowned), you can see the camera team reflected in the little mirror.
Continuity mistake: When the three astronauts move from the "white room" into the viewing room, they all take their helmets off and carry them into the viewing room. They watch the whole 3D show while holding their helmets, but when the show ends, they are no longer holding them, and when the countdown starts, all three helmets can all be seen on the floor back in the white room. (01:26:40)
Continuity mistake: In the scene where they have first entered "the Face" they realize they can take off their helmets. Before they do so, you can see there are tubes going from the backpacks to the helmets, but when the view changes to an overhead shot, the tubes are nowhere to be found.
Continuity mistake: How could Gary Sinise see the reflection of Don Cheadle's hand in the water, when they first met in Mars? Don Cheadle was two or more steps behind his back, so it could never happen that way, unless Don was in the roof, jumping over Gary Sinise.