Revealing mistake: Charlie tells Irene to jump from the moving train when he can't catch up to it. When Irene jumps, the train is standing still. It only appears to be moving because of clever camera manipulation. (00:58:00)
Suggested correction: But if you watch the film carefully, and with both eyes, the train is definitely moving, which is visible.
Plot hole: How on earth is it possible for the three of those babies to fit inside that woman, especially for the size they were when they came out? (00:07:10)
Suggested correction: Only one baby is shown actually coming out before the scene changes so the sizes of the other two are unknown. Also, the three kids were very thin as children and one of the kids became super obese an adult. They simply grew when older so the sizes of all the kids may not of actually played a factor at birth.
Continuity mistake: During the outside motel scene, there is a maroon car parked outside. It changes between a Ford Escort and a Dodge Intrepid. (01:12:50 - 01:20:10)
Suggested correction: It's consistently a Ford Taurus.