Revealing mistake: After Bill Murray breaks through the door with a hammer at Lori's house and says "Here's Johnny", he kicks the door open. On the back of the door you can see white tape, showing where to hit it.
Visible crew/equipment: There is a scene where Bill Murray has to bash open the kitchen door. Right after the door opens, you get a brief view of the back of the door and you can see the area where the door was modified to make it possible to knock the hole in it.
Revealing mistake: In the scene where Lori is putting on her coat as she is passing the curtains on the window there is a glitch and then there is a man walking down the alley way. In the DVD audio commentary the director of the movie admits to this problem. He said they shot this scene in a studio and then put in the man walking down the street later.
Continuity mistake: When Bill Murray is talking to the dead guy in the chair, the dead guy's eyes are open. But from a side shot, they are closed. (00:33:00)