Continuity mistake: When the drunk girl that Andy picks up at the bar throws up on him in the car, only a little hits his face. When they cut to a close-up, his head and face are drenched in pink vomit.
The 40 Year Old Virgin (2005)
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Directed by: Judd Apatow
Starring: Paul Rudd, Steve Carell, Catherine Keener, Romany Malco
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Answer: The video game being played is Mortal Kombat: Deception. It is available for PS2, Gamecube, and XBOX. Based on the controller, I would say they are playing the Nintendo Gamecube version.
Jazetopher