Continuity mistake: Near the end, banditos murder Fred C. Dobbs and leave his stripped body by the waterhole as they go chasing after the burros, which they later try to sell in town. Within hours, Howard and Bob Curtin ride right past the same waterhole on their way to town, but Fred Dobbs' body is nowhere to be seen.
Continuity mistake: When Humphrey Bogart dunks his head in the watering hole, he leans over far enough that his hat is almost entirely submerged. In the next shot, he sets his hat down beside him and only the front portion is wet.