Audio problem: When Dr Gordon is cutting off his foot, the screams from Adam are just a replay of the screams he does at the end of the film. (01:27:05)
Continuity mistake: The bloody bullet wound is seen on Tapp after he's shot. When he is shown after he falls on the ground, the bullet wound is not there. (01:27:50)
Revealing mistake: After Dr. Lawrence cuts off his leg and is crawling towards the gun, if you look at his dismembered leg, you can make out the shape of his foot hidden beneath his ripped up slacks. (01:29:30)
Continuity mistake: The bloody handprint on Lawrence's shoulder that Adam makes at the end is visible before he actually makes it. Second, when Adam finds the tape recorder, it flashes back to Lawrence saying "why?" before Zep tells him it's the rules and the handprint is also visible, but shouldn't be there as Adam made it after he killed Zep. (01:29:40 - 01:33:10)
Revealing mistake: In the scene when Zep arrives in the room and Lawrence is trying to grab at him, his foot is no longer leaving a blood trail. (01:29:45)
Continuity mistake: When Adam pounds on Zep with the toilet seat, he grabs his shoulder in pain. In the first shot of him holding his shoulder, his hand is soaked in blood. In the second shot, however, his hand is much cleaner. (01:30:25)
Revealing mistake: When Adam is searching Zep for the key to the chain once he has found the tape recorder watch Zep's stomach - he's breathing. (01:32:15)
Plot hole: Jigsaw is lying on the ground with a gun in one hand, and a tape recorder in the other; the tape recorder is removed, leaving his hand empty. If both of his hands were occupied/exposed, he would have had no way of depressing the button on the remote control to shock the prisoners. As seen at the end, when he shocks Adam the final time, the control is in his hand, not hidden anywhere else on his body.
Suggested correction: I was under the impression that Zep also had control over the electrocution devices. Jigsaw gave Zep full access to the cameras, so he could see if Lawrence fulfilled his task of killing Adam. It's quite possible that he also gave him access to the electrocution device to ensure that Adam was dead, which it indeed came to.
Audio problem: When Larry goes out into the hall after seeing to his daughter, Ally starts to talk to him but her mouth doesn't move with the words.
Continuity mistake: Jigsaw's thumb moves between shots after Adam gets the mini cassette recorder out of his hands. You can see Jigsaw's thumb, in the closeup shot, slide down to a position where it's lying horizontal and flat on the floor as the mini cassette recorder is being slid out of his hand. In the next shot, an overhead, you can see that his thumb has moved and is now more curled and in a more vertical position to where just the tip is touching the floor. Jigsaw isn't dead, so he could have moved, but this shot is an *instant* cut, he had no time to move.