Cristina Peck: You know what I thought when mom died? I couldn't understand how you could talk to people again, how you could laugh... again. I couldn't understand how you could play with us. And no, no that's a lie, life does not just go on.
Dr. Rothberg: But if you don't come back to the hospital, you're condemning yourself to a terrible death. Your heart won't work anymore. You'll die, asphyxiated. It's an awful death, Paul. You can't imagine it. At least here we can help you to.
Paul Rivers: You can help me die better. That's what you're saying. You can help me die better. Well, I'm not gonna do that, okay? I'd rather die outside.
Paul Rivers: I can't keep going like this. The insemination, the child. It's like we're trying to put a Band-Aid on something that's just been bled dry.
Reverend John: Jesus didn't come to free us from pain. He came to give us the strength to bear it.
Paul Rivers: We have lived on a fraud a long time.
Paul Rivers: They say we all lose 21 grams... who will be next?
Marianne Jordan: Life has to go on Jack. With or without God.
Paul Rivers: Just... disappear.
Jack Jordan: I just ran over a man and two little girls.
Jack Jordan: I'm gonna turn myself in.
Marianne Jordan: What? Why would you do that, Jack?
Jack Jordan: It's my duty.
Marianne Jordan: Your duty's to your family.
Jack Jordan: My duty's to God.
Cristina: Nothing I can do is going to bring them back.
Paul Rivers: We've been a fraud for a long time, Mary.
Answer: The title refers to an experiment in 1907 which attempted to show scientific proof of the existence of the soul by recording a loss of body weight (said to represent the departure of the soul) immediately following death. Referred to as the 21 grams experiment as one subject lost "three-fourths of an ounce" (21.3 grams), the experiment is regarded by the scientific community as flawed and unreliable, though it has been credited with popularizing the concept that the soul weighs 21 grams. (Wikipedia).