Deliberate mistake: In the scene where Maya is looking for Rodney at the party and he scampers off into the bathroom, he miraculously climbs on top of a toilet in a matter of seconds (which isn't actually shown). There is no way a guinea pig could do this.

Dr. Dolittle (1998)
1 deliberate mistake - chronological order
Directed by: Betty Thomas
Starring: Eddie Murphy, Oliver Platt, Peter Boyle, Ossie Davis
Continuity mistake: When he has the accident after hitting the dog, there is a big very noticeable dent in his truck. After he leaves the camp place it is gone and never seen again.
Squirrel #1: ...Bagel chips.
Squirrel #2: Back off, or you'll find your nuts in a tree.
Squirrel #1: Ow! Where's the love?
Trivia: Archer Dolittle's name is never spoken in the film. It is only mentioned in the end credits.
Question: Why did Geno break Mark's nose at the end during the party?
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Answer: Geno deliberately broke Mark's nose during the party after Mark made a snide remark. After the party, when Mark suggested a way to have John committed and still get their money, Geno had enough of Mark's ignorance and punched him in the nose again to add further insult to injury.