Continuity mistake: When the briefcase with the bomb goes in the air and the dog catches it, the dog is nowhere near the wall and he's jumping straight up the first shot of it. But the second shot of the dog, you see him jump off the wall to get it. (00:59:45)
Continuity mistake: In the opening, when the dog is first seen, he's on a leash. Camera cuts and leash disappears.
Continuity mistake: When Striker gets out of the truck after escaping the mental hospital, someone takes a picture. The same exact picture is SUPPOSED to be in the newspaper, but the poses are different.
Continuity mistake: When Elaine is trying to convince Stryker to pilot the shuttle, and his 'drinking problem' starts again, in one shot his shirt is fairly well drenched, the next shot it is drying out, then the next shot shows it drenched again.
Continuity mistake: At some point someone makes a comment about the events that happened in Airplane! the original. They mention that the aircraft involved in the incident was a Boeing 767. In fact, as is quite obvious from the exterior shots in the first film, it is a 707.
Continuity mistake: In Mission Control, a boy thinks one of the screens is a video game. The plane graphic on screen starts spinning some time before the boy messes with the controls.
Continuity mistake: At the hospital, when Ted paints the flowers the jar by his side turns around between shots, note the handle.
Continuity mistake: Before Jimmy's dog is shot at, a woman walks behind Jimmy's mom, but then disappears in the immediate shot that follows.