Factual error: The prisoner is described as carrying an "Axis IV Dissociative Disorder"; that is complete nonsense - dissociative disorders are placed on Axis I in psychiatric diagnoses (Axis I is clinically treatable disorders; Axis II is mental retardation/personality disorders; Axis III is concomitant health problems (e.g., hypertension, diabetes mellitus, CABG, etc.); Axis IV is a list of psychosocial stressors and their severity (e.g., "Moderate - Health problems, financial problems"); Axis V is the GAF score (Global Assessment of Function, scored from 0 - 100). *Any* clinical professional with psychiatric experience would put dissociative disorder on Axis I except for the psychiatrist in the film, who apparently doesn't know any better. (00:54:00)
Revealing mistake: When the woman Ed hit dies, her eyes move. (01:00:30)
Continuity mistake: When Paris is talking to the innkeeper about the orange grove she is buying in Florida, the strap of her purse keeps changing places. Sometimes it is lying over her coat and other times her coat is more open and it is lying across her tee shirt. It goes back and forth throughout the scene. (01:00:35)
Revealing mistake: When John Cusack notices Timmy's mom is dead, you can see her still breathing. (01:01:35)
Revealing mistake: Near the end of the film when we see Rhodes shoot Larry in the chest, you can see an outline of something underneath his vest, very obviously a device/squib simulating being shot in the chest. (01:15:15)
Continuity mistake: When Ed is shot he falls to the ground and his jacket is open exposing the 2 gun shot wounds but when Paris runs over to him his jacket is closed and she has to open it to see his wounds. (01:20:20)
Revealing mistake: When Ed is driving the limo at the beginning of the movie, the gearshift is in the park position.
Plot hole: When the innkeeper is asked by the rich ex-actress to give her the key to a nice room, he gives her a key telling her that eight is cozy and the key has an 8 on it as well. But a few minutes later, when this woman is about to be murdered, she leaves her room (holding her mobile phone) and the door has a 9 on it. How can a key to the room 8 open the door of the room 9? [Still a mistake, but there's an explanation. In the DVD extras you can see a deleted scene in which she changes rooms because she wasn't happy with 8.]
Continuity mistake: At the beginning of the movie, when Paris is singing "For He's a Jolly Good Fellow" to her "client", she licks whipped cream off of a finger on her left hand. When the reverse angle is shown, she's licking a finger on her right hand.
Continuity mistake: When the actress has been killed, and they walk around outside, they are getting all soaked. But when they catch the convict, all of the people are dry, and so are their clothes, even though there's quite a long walk in the rain from the motel to this building.
Revealing mistake: When John Cusack is coming out of the motel grounds looking for Jake Busey, the gate is banging away furiously from the wind but the rain is coming straight down. The rain should be sideways if the gate is banging so much from the wind.
Factual error: The Spanish phrase, "¿Cuál es la punta de vivir?" keeps getting repeated throughout the movie, translated as "what is the point of living?" It's supposedly uttered by a Spanish-speaking person. Guess that person spoke Google Translate; the word "punta" means "point," all right, but it means a geographic point (like "Oyster Point"). The actual phrase in Spanish would be, "¿Cuál es la razón para la vida?"
Character mistake: There's no way that using a regular needle and thread to sew up that wound would work the way it's shown. Anybody who knew what they were doing - which John Cusack is portrayed as knowing - would also know that using unsterilized materials and instruments without a sterile field from an uncleaned massive open wound is a great way to kill your patient.
Suggested correction: The main plot of this film takes place inside the head of a murderer with dissociative identity disorder. The fact that stitching up a wound in that matter wouldn't work is irrelevant to the fact that it is how Malcolm is playing out the scenario in his head.
You're making a good point to invalidate a "character mistake", but couldn't the entry be reclassified as a "factual mistake" and stand as written?