Visible crew/equipment: Very early on in the movie, Neville is happily driving around the deserted streets. Half way through this scene the camera shows us Neville's view out the front windscreen of the car. Ahead, moving cars can be seen crossing the intersection, obviously where the streets hadn't been blocked off for the filming of the movie.
Other mistake: Early in the movie, when Neville wrecks his car he takes the gas can out of his car and starts walking down the street. As he does they switch to a wide view of the city in which you see about three city blocks. When you look at the only "through" street in the shot, there is a car making a left hand turn about three blocks down that street and just behind the car is the freeway overpass with two or three cars passing on it, before the shot ends.
Revealing mistake: In the scene at the stadium where Lisa is helping Neville escape from Mathias' people, it is extremely obvious that in the far shots, it is a stunt man (wearing a very bad grey wig) driving the motorcycle, and Charlton Heston in the close up shots.
Other mistake: In the opening scene where Charlton Heston drives into a Deserted Los Angeles, he drives past at least 3 people walking down the sidewalk. The first person he passes is quite visibly holding up the traffic for the shooting. Another can be seen on the left of the screen when Heston puts the tape on. And one more can be seen in the wide shot of the street. Other than this, the film makers did a great of making LA look deserted.
Continuity mistake: In at least one scene, traffic lights are shown flashing. Where's the power coming from?
Continuity mistake: When Neville flips the car over that he's driving, you see him shooting at the mutants and you can see the tire still turning. The camera angle changes and the tire has stopped turning.
Deliberate mistake: During the opening shot and titles, Neville is shown driving by the same block three times, each from a different angle. The first shot is high, the second shot (00:01:50) is from the hood of the car looking at Neville, and the third (00:02:40) is ground level.
Revealing mistake: When an arrow is shot at Neville, the guide wire for the arrow is visible. (01:27:50)
Visible crew/equipment: When Neville crashes his car, you see an armored car near him. The camera angle changes and you can see the filming crew in the mirror of the truck.
Continuity mistake: When Lisa sees the family marching towards Neville's house, in front of the building on the left is a waste can and a mail box on the opposite corner. When Neville drives by the same building a short time later, there is now a dark car parked in front, two other cars parked on the sidewalk further down the street, and the mail box has moved across the street by the door. (01:25:05 - 01:27:00)
Visible crew/equipment: When Neville and Matthias are fighting, Neville escapes and starts running away. As the camera angle follows him, you can see the shadow from the camera.
Visible crew/equipment: When Neville is jogging, he gets to the last column of a building and you can see the filming crew in the reflection on the left.
Audio problem: When Neville and Lisa are in bed, you hear Lisa talking but her mouth is not moving.
Revealing mistake: When Neville is checking Richie to see how far along he is in the transformation process, while looking in his eyes you can see the white contact lens move.
Continuity mistake: When Neville is in the helicopter with the cure, you can see by the reflection of the trees in the glass that the helicopter is not moving.
Continuity mistake: At the beginning of the movie, Neville crashes the car he is driving and gets out to look over the damage leaving the car door open. He decides to walk away from the car and you see the car door still open. The camera angle changes and the car door is now closed.
Continuity mistake: When Neville slams a mutant into the pile of boxes in the parking garage, there are brown cardboard boxes stacked neatly against the wall, but when the mutant stands up and Neville shoots him, the boxes have disappeared, showing bare wall.
Continuity mistake: When the rich middle aged couple's bodies are in front of the TV set, the man's right arm changes position from resting on the chair's arm rest in the shot over his right shoulder to elevated in the frontal shot.
Revealing mistake: After the helicopter crashes, Neville injects himself in the thigh with a syringe. A thick pad can be seen on his thigh where he stabs the needle.
Visible crew/equipment: Set lights are reflected in the glass of the helicopter before Neville takes off with the cure.