Plot hole: In any given volume of air, there are any number of tiny, living organisms; dust mites, viruses, bacteria, etc. Why did the teleporter combine Seth's DNA only with the fly that was in the chamber? If he had taken the "floating organisms" into account in his calculations and programming, then why would he not have excluded ALL foreign DNA?
The Fly (1986)
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Directed by: David Cronenberg
Starring: Jeff Goldblum, Geena Davis, John Getz, Joy Boushel
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Seth Brundle: I was not pure. The teleporter insists on inner pure. I was not pure.
Ronnie: I don't know what you mean.
Seth Brundle: A fly... got into the... transmitter pod with me that first time, when I was alone. The computer... got confused - there weren't supposed to be two separate genetic patterns - and it decided to... uhh... splice us together. It mated us, me and the fly. We hadn't even been properly introduced.
Trivia: Michael Keaton was the first choice for Seth Brundle.
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Suggested correction: Just because a character doesn't do something that they probably should/could have, it doesn't make it a plot hole. It's arguably a character error.
The correction makes no sense. If the teleporter included the fly's DNA, it would also have included the DNA of - literally - trillions of bacteria, viruses, mites, etc., etc., that are in and around Seth's body. You cannot have it both ways.