Trivia: While Wade talks with Happy, in the background is the red suitcase/armour worn by Tony Stark in Iron Man 2.
Trivia: Before the battle at Cassandra Nova's lair begins, Gambit says "Whoo, I'm about to make a name for myself." A.J. LoCascio, who voices Gambit in X-Men '97, posted a video on his social media of him doing an impression of Channing Tatum's line delivery.
Trivia: During the opening fight scene, Deadpool fights and dances to the song "Bye Bye Bye" by NSYNC. Ironically, this is the same song from X-Men 2 (2003) that briefly plays when Pyro is messing with the car radio during the mansion escape. Wolverine's irritated reaction to the tune is a possible early sign that he and Deadpool won't get along. (Then again, maybe because it was just loud. So, that's anyone's guess.)
Trivia: SPOILER: When Deadpool is facing down the regenerated Deadpool Corp at the end, he tells them that the multiverse thing just isn't working and that they should take the loss. This is a reference to the films of the "Multiverse Saga" of the MCU generally not being as well received as the films from the preceding "Infinity Saga."
Trivia: After 24 years and 10 appearances, this film will mark the first time Hugh Jackman will don Wolverine's classic yellow and blue costume.
Trivia: This is the first movie in the Deadpool series to be filmed in the United Kingdom.