Continuity mistake: David goes downstairs and finds out about his surprise birthday party. The tape recorder and the other objects on the table change position between shots around the ugliest cake ever. (00:05:25)
Other mistake: David's wife is looking inside the microscope at what she describes as a protein found in the saliva. It does not quite look like a protein, and in fact it's a reused (it's exactly the same) microscope image from the previous movie, where Marisa identified it as" a section of the pituitary glans of a Lhasa Apso." (00:12:00 - 00:51:25)
Continuity mistake: David is taking a walk after the exposition scene with his coroner friend and his wife. An Hispanic woman is talking with a douchy realtor; she has her hands and forearms on the table, they are gone from the table at the cut. (00:14:00)
Continuity mistake: David arrived home late for his birthday and his wife is mighty irritated; she serves him on purpose a couple of completely charcoaled steaks. However, the food looks completely different in the close-up (there's much less of it, for starters). (00:15:45)
Continuity mistake: David drops by to the club where the uber-rich baddie is relaxing, and turns out his ideal pastime is dining ringside while hairy wrestlers bodyslam each other on his table. In one of the opening shots he and his associates grab their glasses from the table, but in the wider shot when Professor Tanaka picks up Alexi Smirnoff, their glasses are still on the table, and back in their hands later. (00:20:15)
Continuity mistake: When Smirnoff brutalizes Tanaka's nose, he does it without holding him at first, but he has him in a headlock in the next shot. Even more obvious discontinuity after Hodges' bathroom antics, when Smirnoff has his opponent in a sleeper hold (so he's behind him) but instantly in the next shot he is in front of him and bites his face (all of this with the announcer Count Billy Varga talking continuously). (00:24:20 - 00:24:55)
Continuity mistake: After a close-up on Wildman Jack Armstrong, we see a homeless guy eating with a spoon. He turns around, and in the next shot while still being turned around his left hand traded the food with a flaming stick. (00:28:20)
Revealing mistake: The sequence when Wino Henry gets hit by the tail of the gator and thrown against the wall is all sorts of wrong; in the first part of it, the victim is just standing there in the silliest way and in fact professional bum actor Carmen Filpi 'corpses' waiting for the special effect to happen. In the second part, he's replaced by a poorly disguised stuntman. (00:29:20)
Revealing mistake: The mayor's daughter Sheri hits the villain with a punch that the policemen call "a haymaker" and that hurt her hand. It was anything but; just a bad fake movie punch. (00:30:10)
Continuity mistake: An Hispanic gang approaches David as he is about to have a smoke. He raises his lighter, the head honcho of the gang picks his cigarette, and David raises again the hand he already raised. (00:32:50)
Continuity mistake: When David approaches the homeless guy on the stretcher, he's lying with his hands under the sheet in the first shot, arms crossed on top of the sheet in the next. (00:36:35)
Continuity mistake: Chief Speed and the mayor are talking; Mr. Anderson says "C'mon Clarence, there's a lot at stake this weekend." Clarence Speed is holding a black ID. In the next shot he's holding a pink lighter, the ID is in another spot on the desk. (00:37:20)
Continuity mistake: Thanks to a well-placed compliment about her "backyard", Harmon scores an instant date with the mayor's daughter. They go from the police station to a bar, and somehow en route she has changed hairstyle entirely. (00:40:30)
Continuity mistake: Agent Rich Harmon applies the good old dating strategy of telling a sob story about his childhood. Sheri's hair moves from all in front of her right shoulder, to all in front of the left shoulder (and she is also not holding/ holding her glass). (00:41:10)
Revealing mistake: When the alligator breaks the wall after David failed to kill him with the grenade, the fake jaws are strikingly obvious and completely different from the alligator's look in the part that follows. (00:49:45)
Continuity mistake: When David talks with his wife, the rest of the team and then also Chief Speed outside the manhole, the natural light (quantity of light behind the SUV) changes depending on the camera angle. (00:51:00)
Continuity mistake: When Harmon with a bloody nose suggests that there's gotta be some army ordinance stuff they can use, Sheri next to him has hair all over the left shoulder. It's gone in the wider shot. (00:51:50)
Other mistake: David and the others help out of the sewers one of the alligator hunters. David asks him "who's still down there" and he says "Hawk", but there were other 3 people (relatives and friends, even) besides him; Hawk is the last one alive, sure, but he can't know that. (00:56:55)
Visible crew/equipment: When Brown's limo leaves the scene following Speed's police car, set lights and camera crew are reflected in the side of the vehicle. (00:59:25)
Continuity mistake: When Hodges, Harmon and Hawk put together the 6 sticks of dynamite, Hawk's thumb is below or above Hodges', depending on the angle. (01:03:35)