Trivia: Charlie Cox was told by Marvel to see this film on its opening weekend so that he could see the crowd's reaction to his surprise cameo. He went to a theatre in his hometown in Connecticut and was snuck into the theatre by the manager. It turns out that his appearance elicited no significant reaction from the crowd, with a lone member of the audience saying, "Oh, cool."
Trivia: Although they are friends in real life, neither Andrew Garfield nor Charlie Cox knew the other was in this film. Cox texted Garfield when he arrived in Atlanta for shooting and said he thought they were doing a film together, as Garfield was heavily rumoured to be in it. Garfield responded by saying he was filming "SM," to which Cox affirmed they were doing the same film. Garfield then clarified that "SM" meant "Spider-Man," to which Cox also affirmed. It turns out they weren't in each other's scripts.
Trivia: SPOILER: Although it was the film's worst kept secret, whenever asked, Andrew Garfield would deny, sometimes vehemently, that he would be appearing in it.
Trivia: Spider-Man asking Doctor Strange to cast a spell in order to make people forget that he is Peter Parker is similar to the comics storyline "One More Day." After the events of "Civil War" where Spider-Man revealed his secret identity to the world, he made a deal with Mephisto to save Aunt May's life in exchange for Mephisto nullifying Peter's marriage to Mary Jane Watson. As part of the deal, Mephisto erased everyone's memory of Spider-Man being Peter Parker.
Trivia: Electro is surprised to learn that Spider-Man isn't black because he is from Queens and helps other people. He then ponders that there may be a black Spider-Man in another universe, a reference to Miles Morales.
Trivia: Tobey Maguire and Andrew Garfield snuck into a theater together to watch the film.
Trivia: !MASSIVE SPOILER ALERT! YOU HAVE BEEN WARNED!"Spider-Man: No Way Home" features the first on-screen appearance of Tobey Maguire's Spider-Man in 14 years, since the release of "Spider-Man 3" in 2007. It also features the first on-screen appearance of Andrew Garfield's Spider-Man in 7 years, since the release of "The Amazing Spider-Man 2" in 2014. The film's multiverse-based story allowed them to return and interact with one-another and Tom Holland's version of the character.
Trivia: This is the first live-action Spider-Man film to not be released during the summer movie season.
Trivia: !SPOILERS! Despite their prominent appearances in the film, being featured in most of the third act in multiple major sequences, Tobey Maguire and Andrew Garfield were actually only on-set for a surprisingly short two weeks. For reference, filming for the entire movie took just over five months, meaning they were on-set for less than 10% of the total shoot.
Trivia: SPOILER: Prior to the final battle, the Tobey Maguire version of Spider-Man complains about his sore back. Maguire nearly had to drop out of Spider-Man 2 because of back injuries.
Trivia: SPOILER: Prior to the film's release, unconfirmed reports stated Charlie Cox would appear in the film as Matt Murdock, reprising his role from the Netflix series Daredevil. Marvel Studios President Kevin Feige practically spilled the beans days before the release, stating that if the day ever came that Marvel would use the Daredevil character in their films, Cox would be playing him. The episode of Hawkeye that premiered the day before this film's release all but confirmed this, as Vincent D'Onofrio was revealed to be reprising his role as Kingpin from the aforementioned Daredevil series.
Trivia: Jamie Foxx apparently didn't know that Tobey Maguire's and Andrew Garfield's returns were meant to be a secret, and he nearly spoiled it by taking a picture of the two together with Tom Holland and posting it on Instagram before a crewmember stopped him.
Trivia: !SPOILERS! Tobey Maguire and Andrew Garfield gave a lot of notes on their characters, which the writers gratefully accepted. For example, Maguire didn't want too much revealed about what's been happening with his Peter, aside from the fact that he was still with Mary Jane. (Presumably to leave his adventures up to the fans' imaginations.) And Garfield wanted his Peter to be a bit more ferocious/emotional compared to his first two films to show how Gwen Stacey's death changed him.
Trivia: Spoiler Alert: When Sandman and Lizard are cured and turned back into humans, the footage of them in their human forms is actually digitally manipulated stock footage and alternate takes from their respective original films. Ex. When Sandman turns human, it's using manipulated stock footage from the subway fight scene in "Spider-Man 3." When Lizard is turned human, it appears to be an alternate angle/B-roll from footage featured in the final battle of "The Amazing Spider-Man."