Revealing mistake: When they are learning how to throw knives, the guy gets one thrown through his hand. If you watch this carefully, blood starts coming out of his hand before the knife hits. (00:28:45)
Revealing mistake: When Rico jumps on to the back of the tanker alien and starts shooting at its back, you can see the outline on the back of the tanker that is going to be shot up before Rico starts shooting.
Revealing mistake: During the last play of the football game, Dizzy throws Rico the ball and he does an impressive flying flip over several players. Right before the flip, it's extremely obvious that Rico runs up an off camera ramp/stairway in order to perform this flip.
Revealing mistake: Just before Dizzy gets skewered by a warrior bug, you can see breakaway panels on her body armor at the points where the CGI bug impales her, to cover the squibs used to make the holes. The shot is already shown in slow-mo so it's easy to spot.
Chosen answer: They do use nukes (to clear out bug caves) and fuel-air bombs (like they do before landing troops). It's possible biological and chemical weapons don't work on the bugs because of their physiology. Only nukes and Thermobaric weapons work.
lionhead