Directed by: Gore Verbinski
Starring: Jason Isaacs, Dane DeHaan, Mia Goth, Ivo Nandi
Volmer: Do you know what the cure for the human condition is? Disease. Because that's the only way one could hope for a cure.
Volmer: Most of my patients have done extraordinary things. Built vast fortunes, commanded great empires... but at a terrible cost. They have no-one who cares from them.
Factual error: The license plate of the car that takes the protagonist to the sanitarium is GR 36E46. That's not a valid Swiss plate: GR indicates the canton of Graubünden, but other than that it is supposed to have only digits and no letters.
Trivia: When Lockhart is in the sensory deprivation tank, the nurse that does a poor job of keeping an eye on him is reading "Der Zauberberg" by Thomas Mann, which obviously has at that point a common premise with the movie (the main character goes to a sanatorium in the Alps just as a visitor but ends up as an inmate). The novel was inspired by Mann's visit to his wife at a Swiss sanatorium which happened in 1912, same year as the picture fully unveiled in the finale.
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Answer: As a result of the tortures he endured at the hospital, Lockhart lost his mind. At the end, as he pedals away from the hospital and down the road, he grins maniacally because he is now quite mad.
Charles Austin Miller