Factual error: Federal institutions have strict rules for inmates or patients based on the reason for their incarceration, including substituting metal utensils with safer plastic ones. Despite being convicted of brutally killing his family, Myers is still trusted with a sharp metal fork - resulting in the nurse's death.
Plot hole: When Bridgette ran through the glass and Linda and Jim were at the hospital Jim tells Linda he called her mom and told her what happened and she was coming to stay over the next day. Yet apparently her mom forgot what happened because she had her committed because Linda didn't remember what happened to Bridgette's face. Also, Bridgette was like 9. How come no-one just asked her what happened?
Continuity mistake: At the start, Robert Neville drives into some yellow poles, only to drive into them again in the following shot.
Audio problem: When the cop saves the girl from the mob of locals, his car tires squeal as he accelerates away, but the car is on loose dirt, which makes the squealing impossible.
Continuity mistake: When Amber and Jonesy get an arrow through the head, the cannibal was on Jonesy's side, so the tip should have gone through Amber's head, not Jonesy's.
Continuity mistake: When the car door is ripped off by the cow, it shows the truck with the door intact.
Visible crew/equipment: At the start of the film, just after the war exercise, when the Sergeant begins yelling at the recruits you can see the outline of his microphone under his T-Shirt. (It's not his dog tags because you can see the shape and dog tags are not shaped like that.)
Revealing mistake: As Carlos is giving his final goodbyes to Claire you can see in the background automobiles driving down the freeway. Shouldn't these roads be empty rather than having what seems to be a thriving highway? (01:10:00)
Suggested correction: Not a single car in the background.
Visible crew/equipment: Before Lorna has her throat slashed, you can see a tube pumping the blood.
Continuity mistake: The birth of the Predalien in this movie is completely different than it was in the first AVP. The lights on the table are different and the Predalien bursts out differently than in the first film. (00:01:30)
Visible crew/equipment: Several times in the movie you can see a stunt double for Donnie Wahlberg, like when he tries to hang himself. Art runs over and there is a wide shot focusing on both of them. No slo-mo required, but you can see it's a stunt double.
Revealing mistake: During the heavy snowstorm, the telephone wires are still, even though it's a blizzard.
Visible crew/equipment: When Jamie leaves his father's house to meet Henry at the theatre, a member of the production crew can be seen standing behind a bush in the garden as his car reverses.
Suggested correction: It's the gardener seen earlier in the film when Jamie first arrives.
Continuity mistake: As Mike scrolls through the microfilm, we see his view as the pages scroll from right to left. The shot then reverses to show his face through the scrolling film, but while the film is now properly reversed, it's still moving right to left in our view. But this reversed angle should show it moving left to right. (00:12:05)
Continuity mistake: At the beginning, in the scene where Rayne finds two bodies near a small house, she takes out one of her blades. Firstly, she grabs it in a wrong way (the tonfa-like blades should be held under the arm), but when the camera angle changes she holds it properly.
Visible crew/equipment: In the scene where Doyle is talking to the helicopter pilot at the park, you can see another pilot on the left side of Doyle's head for a split second. (01:14:50)
Factual error: There is a scene near the beginning of the movie when the mist has just begun. A firetruck roars by, and has Caddo Parish Fire Dept. on the side. This movie is set in Maine. Louisiana is the only state with parishes. All others, including Maine, have counties. (00:10:50)
Continuity mistake: In the scene where the mother, Denise, is finally beginning to believe their house may be haunted, and is questioning Ben as to whether or not he can see them, Ben points out the window. When Ben points, you can see that the curtain is over the window. When Denise looks back, the curtain is wide open so she can see the barn. When she looks back to Ben, the curtain is again closed.
Continuity mistake: The next morning after they have been attacked, the car windscreen that was smashed is now untouched.
Continuity mistake: In the scene at the dance, where the pumpkin pours cockroaches all over Priscilla, she falls over onto the cake. When she first falls onto the cake, she's just wearing tights and no shoes. In the next shot, she's wearing black shoes.