Factual error: At one point, a screencast of a computer screen shows a video of Barry Brickman on the desktop environment of Windows XP (operating system, developed by Microsoft, released in 2001). However, the app that plays the video is QuickTime for Mac (which runs on Mac OS only), not QuickTime for Windows (which runs on Windows XP). These two versions of QuickTime are almost identical in every respect, except for their title bar (the narrow horizontal area above the video). (00:19:15)
Factual error: When the Toad's foot breaks the pipe of liquid nitrogen, it should have frozen the water immediately, but it takes a lot more time to allow the wave to get closer.
Factual error: During the "University Challenge" competition: Brian answers a question with "Calcium Sulphite" and the question-master says he gave the correct answer of "Calcium Sulphate" (a different compound).
Factual error: The two uniformed police officers who take Dargis away at the end have haircuts that touch their collars. Plain clothed officers are allowed to be less stringent about their appearance, uniformed officers are most certainly not, and long hair like that simply doesn't happen.
Factual error: In the scene where the rocket launcher is fired and blows up the plane, the sound should have been delayed a second or two after the plane exploding.
Factual error: An AED delivers an electric shock for a fraction of a second. It is not capable of producing a sustained current, as is depicted in the movie when Roger and Dr. P are being electrocuted.